Loss of conserved ubiquitylation sites in conserved proteins during human evolution

International Journal of Molecular Medicine
Dongbin ParkYoonsoo Hahn

Abstract

Ubiquitylation of lysine residues in proteins serves a pivotal role in the efficient removal of misfolded or unused proteins and in the control of various regulatory pathways by monitoring protein activity that may lead to protein degradation. The loss of ubiquitylated lysines may affect the ubiquitin‑mediated regulatory network and result in the emergence of novel phenotypes. The present study analyzed mouse ubiquitylation data and orthologous proteins from 62 mammals to identify 193 conserved ubiquitylation sites from 169 proteins that were lost in the Euarchonta lineage leading to humans. A total of 8 proteins, including betaine homocysteine S‑methyltransferase, clin and CBS domain divalent metal cation transport mediator 3, ribosome‑binding protein 1 and solute carrier family 37 member 4, lost 1 conserved lysine residue, which was ubiquitylated in the mouse ortholog, following the human‑chimpanzee divergence. A total of 17 of the lost ubiquitylated lysines are also known to be modified by acetylation and/or succinylation in mice. In 8 cases, a novel lysine evolved at positions flanking the lost conserved lysine residues, potentially as a method of compensation. We hypothesize that the loss of ubiquitylation sites during evo...Continue Reading

References

Nov 1, 1972·Archives of Biochemistry and Biophysics·J D FinkelsteinW E Kyle
Apr 3, 2004·Genome Research·Mathieu BlanchetteWebb Miller
Mar 17, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Cécile CaronSaadi Khochbin
Aug 2, 2005·Nature Cell Biology·Zhijian J Chen
Sep 2, 2005·Nature·Wen-Hsiung Li, Matthew A Saunders
Dec 13, 2005·Genome Research·Ajit Varki, Tasha K Altheide
Jun 7, 2006·Annual Review of Cell and Developmental Biology·Oliver KerscherMark Hochstrasser
Jul 24, 2007·Molecular Biology and Evolution·Yoonsoo HahnByungkook Lee
Nov 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Alan M MosesRichard Durbin
Dec 19, 2007·PLoS Computational Biology·Jingchun ZhuDavid Haussler
Feb 8, 2008·The Biochemical Journal·Abdallah K Al-HakimDario R Alessi
Jun 12, 2008·International Review of Cell and Molecular Biology·Irina M KonstantinovaAlexey G Mittenberg
Oct 24, 2008·Journal of Receptor and Signal Transduction Research·Ok-Jin Kim
Sep 6, 2011·Molecular & Cellular Proteomics : MCP·Sebastian A WagnerChunaram Choudhary
Sep 13, 2011·Molecular Cell·Woong KimSteven P Gygi
Apr 25, 2012·Annual Review of Biochemistry·David Komander, Michael Rape
May 17, 2012·Molecular BioSystems·Tzachi HagaiYaakov Levy
Jun 20, 2012·Clinical Proteomics·Deepthi TelikicherlaAkhilesh Pandey
Nov 20, 2012·BMC Bioinformatics·Dong Seon Kim, Yoonsoo Hahn
Jun 29, 2013·Molecular Cell·Jeongsoon ParkYingming Zhao
Aug 21, 2013·Cytokine & Growth Factor Reviews·Xing LiuChen Wang
Apr 22, 2014·Current Topics in Membranes·Janice Y Chou, Brian C Mansfield
Jun 27, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zinia IslamAkira Kato
Aug 26, 2014·Frontiers in Molecular Neuroscience·Katarina StojkovicNicolas Cermakian
Oct 18, 2014·Frontiers in Molecular Neuroscience·Zaira Ortega, Jose J Lucas
Nov 7, 2014·Nature Medicine·Doris PopovicIvan Dikic
Nov 28, 2014·Nucleic Acids Research·Kate R RosenbloomW James Kent
Jan 30, 2015·BMC Bioinformatics·Dong Seon Kim, Yoonsoo Hahn
Apr 19, 2015·BMB Reports·Hye Ji OhYoonsoo Hahn
Oct 16, 2015·International Journal of Molecular Medicine·Dong Seon KimYoonsoo Hahn
Oct 21, 2015·Advances in Biological Regulation·Cristina Azevedo, Adolfo Saiardi
Jan 1, 2016·PLoS Genetics·Jorge Ruiz-OreraM Mar Albà

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Citations

Aug 28, 2021·International Journal of Molecular Sciences·Hao-Lun LuoJei-Ming Peng

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