Loss of diacylglycerol kinase epsilon in mice causes endothelial distress and impairs glomerular Cox-2 and PGE2 production

American Journal of Physiology. Renal Physiology
Jili ZhuMassimo Attanasio

Abstract

Thrombotic microangiopathy (TMA) is a disorder characterized by microvascular occlusion that can lead to thrombocytopenia, hemolytic anemia, and glomerular damage. Complement activation is the central event in most cases of TMA. Primary forms of TMA are caused by mutations in genes encoding components of the complement or regulators of the complement cascade. Recently, we and others have described a genetic form of TMA caused by mutations in the gene diacylglycerol kinase-ε (DGKE) that encodes the lipid kinase DGKε (Lemaire M, Fremeaux-Bacchi V, Schaefer F, Choi MR, Tang WH, Le Quintrec M, Fakhouri F, Taque S, Nobili F, Martinez F, Ji WZ, Overton JD, Mane SM, Nurnberg G, Altmuller J, Thiele H, Morin D, Deschenes G, Baudouin V, Llanas B, Collard L, Majid MA, Simkova E, Nurnberg P, Rioux-Leclerc N, Moeckel GW, Gubler MC, Hwa J, Loirat C, Lifton RP. Nat Genet 45: 531-536, 2013; Ozaltin F, Li BH, Rauhauser A, An SW, Soylemezoglu O, Gonul II, Taskiran EZ, Ibsirlioglu T, Korkmaz E, Bilginer Y, Duzova A, Ozen S, Topaloglu R, Besbas N, Ashraf S, Du Y, Liang CY, Chen P, Lu DM, Vadnagara K, Arbuckle S, Lewis D, Wakeland B, Quigg RJ, Ransom RF, Wakeland EK, Topham MK, Bazan NG, Mohan C, Hildebrandt F, Bakkaloglu A, Huang CL, Attanasio M. ...Continue Reading

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Citations

Nov 3, 2016·Frontiers in Cell and Developmental Biology·Richard M EpandMathieu Lemaire
Mar 1, 2017·Lancet·Fadi FakhouriChantal Loirat
Jul 2, 2020·Clinical Science·Gianluca BaldanziMario Malerba
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Nov 27, 2019·International Journal of Molecular Sciences·Gianluca Baldanzi, Mario Malerba
Mar 21, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wenjun FuLiangzhong Sun
Jul 20, 2021·Journal of Cellular Physiology·Santosh K YadavDeepak A Deshpande

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