Loss of disialyl Lewis(a), the ligand for lymphocyte inhibitory receptor sialic acid-binding immunoglobulin-like lectin-7 (Siglec-7) associated with increased sialyl Lewis(a) expression on human colon cancers

Cancer Research
Keiko MiyazakiReiji Kannagi

Abstract

Expression of sialyl Lewis(a) is known to be increased in cancers of the digestive organs. The determinant serves as a ligand for E-selectin and mediates hematogenous metastasis of cancers. In contrast, disialyl Lewis(a), which has an extra sialic acid attached at the C6-position of penultimate GlcNAc in sialyl Lewis(a), is expressed preferentially on nonmalignant colonic epithelial cells, and its expression decreases significantly on malignant transformation. Introduction of the gene for an alpha2-->6 sialyl-transferase responsible for disialyl Lewis(a) synthesis to colon cancer cells resulted in a marked increase in disialyl Lewis(a) expression and corresponding decrease in sialyl Lewis(a) expression. This was accompanied by the complete loss of E-selectin binding activity of the cells. In contrast, the transfected cells acquired significant binding activity to sialic acid-binding immunoglobulin-like lectin-7 (Siglec-7)/p75/adhesion inhibitory receptor molecule-1, an inhibitory receptor expressed on lymphoid cells. These results indicate that the transition of carbohydrate determinants from disialyl Lewis(a)-dominant status to sialyl Lewis(a)-dominant status on malignant transformation has a dual functional consequence: the l...Continue Reading

References

Sep 16, 1991·Biochemical and Biophysical Research Communications·A TakadaR Kannagi
Dec 15, 1986·Chemistry and Physics of Lipids·S Hakomori
May 16, 1997·International Journal of Cancer. Journal International Du Cancer·H ItoR Kannagi
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·C MitsuokaR Kannagi
Jun 18, 1999·Glycoconjugate Journal·D R MackM A Hollingsworth
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·C VitaleM C Mingari
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Senitiroh Hakomori
Dec 5, 2002·Current Opinion in Structural Biology·Paul R Crocker

❮ Previous
Next ❯

Citations

Jun 4, 2008·Glycoconjugate Journal·Keiko Akasaka-ManyaTamao Endo
Jun 19, 2012·Clinical Epigenetics·Tomislav HorvatGordan Lauc
May 2, 2012·Proceedings of the National Academy of Sciences of the United States of America·Keiichiro SakumaReiji Kannagi
Apr 28, 2011·The Journal of Biological Chemistry·Kazuhiro ShiozakiTaeko Miyagi
May 31, 2014·World Journal of Gastroenterology : WJG·Yoshinori InagakiWei Tang
Mar 28, 2013·TheScientificWorldJournal·Fumiko TaniuchiKojiro Matsumoto
Feb 8, 2014·Omics : a Journal of Integrative Biology·Eun Ji JooRobert J Linhardt
May 21, 2008·Nature Immunology·Yvette van Kooyk, Gabriel A Rabinovich
Sep 26, 2009·Toxicology Mechanisms and Methods·Abdollah RamzanigharaDavinder K Dhawan
Oct 27, 2007·Biochimica Et Biophysica Acta·Taeko Dohi, Yuki I Kawamura
May 11, 2004·Cancer Science·Reiji KannagiNaoko Kimura
Dec 6, 2007·Journal of Neurochemistry·Roger A KroesJoseph R Moskal
Oct 1, 2010·Biomolecular Concepts·Vlatka ZoldošGordan Lauc
Dec 10, 2014·Cellular and Molecular Life Sciences : CMLS·Kayluz Frias BoliganStephan von Gunten
Sep 23, 2016·Digestive Diseases and Sciences·Andrew S AllegrettiRavi I Thadhani
May 10, 2017·International Journal of Molecular Sciences·Fabio Dall'Olio, Marco Trinchera
Mar 5, 2017·Immunological Reviews·Isabella Fraschilla, Shiv Pillai
Apr 29, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jishun Lu, Jianguo Gu
Apr 5, 2018·International Journal of Molecular Sciences·Chin-Han HuangYuh-Ching Twu
Jul 15, 2005·Glycobiology·Ajit Varki, Takashi Angata
Jun 22, 2019·Science·Christopher J Halbrook, Howard C Crawford
Jul 25, 2019·Organic & Biomolecular Chemistry·Ingrid M E 't HartGeert-Jan Boons
Aug 12, 2014·World Journal of Gastroenterology : WJG·Francesco MarianiLuca Roncucci
Nov 26, 2004·The Journal of Biological Chemistry·Bruce S BochnerRonald L Schnaar
Nov 22, 2018·PloS One·Yuhsuke OhmiKeiko Furukawa
Dec 17, 2010·World Journal of Hepatology·Kenta Moriwaki, Eiji Miyoshi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.