Loss of E-cadherin and beta-catenin is correlated with poor prognosis of ampullary neoplasms

Journal of Surgical Oncology
Hui-Ping HsuPin-Wen Lin

Abstract

Distant metastasis resulting from carcinoma cell detachment from the primary tumor involves modification of adhesion molecules. This study was conducted to examine the correlation of E-cadherin/beta-catenin expression with survival and recurrence in ampullary neoplasms. Patients with diagnoses of ampullary neoplasms were enrolled in the study. Demographics, operative findings, and histopathological data were collected by retrospective chart review. Expression of E-cadherin and beta-catenin were detected by immunohistochemistry. A total of 110 patients were enrolled in the study. Preservation of membranous staining of E-cadherin was noted in 41 (37%) patients, aberrant cytoplasmic staining in 48 (44%) patients, and complete loss in 21 (19%) patients. Loss of E-cadherin was associated with pancreatic invasion, recurrence, and poor prognosis. Membranous staining of beta-catenin was noted in 65 (59%) patients, cytoplasmic or nuclear accumulation in 16 (15%) patients, and complete loss in 29 (26%) patients. Loss of beta-catenin expression was associated with tumor markers, ulcerative type, liver metastases, and poor prognosis. Pancreatic invasion, lymph node involvement, and loss of beta-catenin expression were predictors of disease...Continue Reading

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Citations

Aug 24, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Christina L RolandJason B Fleming
Sep 28, 2010·The American Journal of Surgical Pathology·Nobuyuki OhikeNazmi Volkan Adsay
Feb 7, 2012·International Journal of Cancer. Journal International Du Cancer·Weiren LuoKaitai Yao
Jan 25, 2014·Histopathology·Iraklis PerysinakisGregory Kouraklis
May 3, 2016·Journal of Surgical Oncology·Eisuke AsanoUNKNOWN Shikoku Consortium of Surgical Research (SCSR)
Nov 11, 2019·Scientific Reports·Chih-Yang WangHui-Ping Hsu
Aug 21, 2016·International Journal of Surgical Pathology·Iraklis PerysinakisGregory Kouraklis
Aug 11, 2020·Surgical Pathology Clinics·Yue Xue, Michelle D Reid

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