Loss of elastic fibers causes skin wrinkles in sun-damaged human skin

Journal of Dermatological Science
Jin Young LeeJin Ho Chung

Abstract

Although wrinkling is the most obvious sign of aged skin, the detailed pathomechanism of wrinkle development has not been elucidated. In this study, we investigated the role of elastic fibers in the formation of skin wrinkles. Loss of elastic fibers was measured quantitatively in the facial skins of subjects representing seven decades, and then compared with wrinkle severities. We also investigated whether topical retinoic acid treatment to photoaged human skin can restore destroyed elastic fiber, and the correlation between wrinkle improvement with increase in elastic fibers in RA-treated facial skin. We found a significant correlation between decreases in the length, width, number and total area of oxytalan fibers and wrinkle severity. Furthermore, we found that topical application of retinoic acid (0.025%) to chronically photodamaged skin regenerated and restored elastic fibers, and that there was a significant positive correlation between the amount of newly regenerated elastic fiber and the wrinkle improvement caused by retinoic acid. Our results provide an objective insight into the role of elastic fibers in skin wrinkle formation by providing a quantitative correlation between changes in oxytalan fibers and the severity ...Continue Reading

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Citations

Dec 17, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jennifer L MacGregor, Jeffrey S Dover
May 27, 2011·Maturitas·Elizabeth C NaylorMichael J Sherratt
Mar 1, 2012·Journal of Cosmetic Dermatology·Philippe HumbertPatrice Muret
Aug 26, 2010·Journal of Oral Rehabilitation·K NakagawaT Ueda
Feb 4, 2014·The British Journal of Dermatology·A K LangtonR E B Watson
Dec 4, 2014·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Y ShiiharaN Yoshikawa
Apr 18, 2012·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Borut PoljsakRaja Dahmane
Dec 9, 2014·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Jae Hoon JeongSukwha Kim
Jan 31, 2019·Experimental Dermatology·Yumiko YamawakiHitoshi Masaki
Oct 5, 2010·Journal of Cosmetic Dermatology·Eve MerinvilleAurelie C Laloeuf
Apr 16, 2014·Plastic and Reconstructive Surgery·Adrian McArdleMichael T Longaker
Aug 13, 2015·The Journal of Craniofacial Surgery·Yingfang FanSukwha Kim
Oct 29, 2020·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Kohei YamazakiShingo Sakai
Jan 19, 2021·The Journal of Dermatology·Chao-Chun YangHamm-Ming Sheu
May 28, 2021·Mechanisms of Ageing and Development·Holly N Wilkinson, Matthew J Hardman
Jul 9, 2021·ACS Applied Materials & Interfaces·Chuang WangJuming Yao

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