Loss of enterocyte mass is accompanied by diminished turnover of enterocytes after myeloablative therapy in haematopoietic stem-cell transplant recipients

Annals of Oncology : Official Journal of the European Society for Medical Oncology
J P M DerikxW A Buurman

Abstract

Intestinal mucosal barrier injury (MBI), resulting from myeloablative conditioning for haematopoietic stem-cell transplantation (HSCT), is an important cause of morbidity. Despite its frequency, recognition presents a challenge, while the aetiology needs still to be unravelled. The relationship between enterocyte mass and enterocyte loss was explored by examining citrulline serum levels and by assessing circulating intestinal fatty acid-binding protein (I-FABP) and ileal bile acid-binding protein (I-BABP), proteins released by dying mature enterocytes. Thirty-four adult patients with haematological malignancy received allogeneic HSCT (HSCT day 0) 12 days after being given idarubicin, cyclophosphamide and total body irradiation as myeloablative conditioning, a regimen known to induce oral and intestinal MBI. Serum levels of citrulline, I-FABP and I-BABP were measured on HSCT days -12, -6, 0, +7, +14 and +21. Myeloablative conditioning resulted in a significant decrease in serum citrulline with the nadir on HSCT day +7; thereafter, levels rose gradually. Simultaneously, a significant decrease in I-FABP and I-BABP levels occurred from the day of transplant until day +14. Simultaneous reduction and subsequent increase of citrulline...Continue Reading

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Citations

Feb 2, 2011·Journal of Veterinary Internal Medicine·O DossinJ P Schoeman
Dec 18, 2008·PloS One·Joep P M DerikxWim A Buurman
Jun 24, 2014·Pediatric Research·Kostan W ReisingerTim G A M Wolfs
Feb 2, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Samuel VokurkaLadislav Trefil
Oct 19, 2016·Critical Care : the Official Journal of the Critical Care Forum·Petrus R de JongNicolaas J G Jansen
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Feb 27, 2016·American Journal of Veterinary Research·Julien M DahanOlivier Dossin
May 26, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·N S S KuikenWim J E Tissing
Aug 12, 2014·Journal of Pediatric Gastroenterology and Nutrition·Kostan W ReisingerJoep P M Derikx
Oct 28, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Per T SangildMathias Rathe
Nov 21, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Armin RashidiDaniel J Weisdorf

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