PMID: 9185712Jun 11, 1997Paper

Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma

International Journal of Cancer. Journal International Du Cancer
D J EastyD C Bennett

Abstract

Protein tyrosine kinases (PTKs) have been implicated in the development of many common human tumours including melanoma. Previously we isolated PTK gene sequences expressed in normal melanocytes. Here we examined expression of 9 of these genes in cell lines derived from defined stages of melanoma progression, by Northern blotting and in some cases immunoblotting. We also tested cells from 2 animal models of particular stages in progression, as well as uncultured biopsies of metastatic melanoma. The expression of 2 receptor kinase family members found in melanocytes, PTK7/CCK-4 and SEK/TYRO1, was decreased or lost in advanced melanomas. PTK7 mRNA was found in only 54% of melanoma cell lines and 20% of melanoma biopsies. Similarly, expression was lost in 2 advanced cell lines selected from an early melanoma line that did express PTK7 mRNA. SEK/TYRO1 expression was observed in 75% and 17% of cell lines from primary and metastastic melanomas, respectively. Conversely, mRNA for the non-receptor kinase PTK6/BRK was not detected in normal melanocytes or primary melanoma lines, but was found in 9% of metastatic melanoma cell lines.

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Citations

Dec 22, 1999·Oncogene·K MaungD C Bennett
Jul 27, 2000·Molecular and Cellular Biology·J J DerryA L Tyner
Aug 30, 2008·The Journal of Biological Chemistry·Roberta NoberiniElena B Pasquale
May 22, 2009·Expert Opinion on Therapeutic Targets·Takuya Sato, Noriko Gotoh
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May 3, 2012·Cancer Metastasis Reviews·Mustapha Kandouz
Aug 7, 2012·Journal of Cellular and Molecular Medicine·Hong-Qing XiLin Chen
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Dec 3, 2015·World Journal of Biological Chemistry·Tadashi MatsudaKenji Oritani
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