Loss of Fas expression and high expression of HLA-E promoting the immune escape of early colorectal cancer cells

Oncology Letters
Renxiang HuangZhijun Bao

Abstract

Previous studies have investigated the mechanisms of immune evasion of tumor cells in numerous types of advanced solid malignant tumor, and several types of immune preparations have been administered as antitumor adjuvant therapies. However, in the majority of studies, the efficacy of therapies has been revealed to be limited. The present study aimed to investigate the immune evasion mechanisms employed by early colorectal cancer cells and the expression of the molecules associated with immune evasion during the malignant transformation process of normal colorectal epithelial cells to measure the effects of immune intervention for early colorectal cancer, and to improve the efficacy of immunotherapy. A total of 60 colorectal tissues, including 15 normal mucosa, 15 adenoma, 15 early cancer and 15 advanced cancer tissues, from patients undergoing endoscopic procedures in Huadong Hospital Affiliated to Fudan University (Shanghai, China) were collected. A comparison of baseline characteristics among these four groups was performed. The expression levels of human leukocyte antigen-A (HLA-A), apoptosis antigen 1 (Fas), c-c chemokine receptor type 5 (CCR5), Fas ligand (FasL) and HLA-E in each group were detected by immunohistochemical...Continue Reading

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Citations

Oct 13, 2017·International Journal of Molecular Sciences·Asma Beldi-Ferchiou, Sophie Caillat-Zucman
Feb 22, 2018·Annals of Hematology·Zhiheng ChengLin Fu
Aug 27, 2018·Journal of Cellular Biochemistry·Hui LiYao-Zhou Tian
Apr 23, 2019·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Mepur H RavindranathShahab Asgharzadeh
Nov 7, 2019·International Journal of Molecular Sciences·Leonid KanevskiyElena Kovalenko
Jul 26, 2019·Cancers·Ziqing ChenAndreas Lundqvist
Mar 22, 2019·Archives of Pharmacal Research·Nayoung KimHun Sik Kim
Nov 28, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiao ZhuHui Luo
Oct 31, 2020·Signal Transduction and Targeted Therapy·Yuqing CaoFeng Xu
Feb 27, 2021·Clinical and Translational Medicine·Shaikha AlMusawiAbdolrahman S Nateri

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Methods Mentioned

BETA
biopsy

Software Mentioned

Statistical Analysis System

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