Loss of galectin-3 decreases the number of immune cells in the subventricular zone and restores proliferation in a viral model of multiple sclerosis

Glia
Rachel E JamesFrancis G Szele

Abstract

Multiple sclerosis (MS) frequently starts near the lateral ventricles, which are lined by subventricular zone (SVZ) progenitor cells that can migrate to lesions and contribute to repair. Because MS-induced inflammation may decrease SVZ proliferation and thus limit repair, we studied the role of galectin-3 (Gal-3), a proinflammatory protein. Gal-3 expression was increased in periventricular regions of human MS in post-mortem brain samples and was also upregulated in periventricular regions in a murine MS model, Theiler's murine encephalomyelitis virus (TMEV) infection. Whereas TMEV increased SVZ chemokine (CCL2, CCL5, CCL, and CXCL10) expression in wild type (WT) mice, this was inhibited in Gal-3(-/-) mice. Though numerous CD45+ immune cells entered the SVZ of WT mice after TMEV infection, their numbers were significantly diminished in Gal-3(-/-) mice. TMEV also reduced neuroblast and proliferative SVZ cell numbers in WT mice but this was restored in Gal-3(-/-) mice and was correlated with increased numbers of doublecortin+ neuroblasts in the corpus callosum. In summary, our data showed that loss of Gal-3 blocked chemokine increases after TMEV, reduced immune cell migration into the SVZ, reestablished SVZ proliferation and incre...Continue Reading

References

Jun 1, 1980·The Journal of Cell Biology·K D McCarthy, J de Vellis
May 5, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C ColnotF Poirier
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H SanoF T Liu
Aug 15, 2000·European Journal of Immunology·A NansenA R Thomsen
Sep 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Nathalie Picard-RieraAnne Baron-Van Evercooren
Mar 26, 2003·The American Journal of Pathology·Ikuo TsunodaRobert S Fujinami
Oct 24, 2003·The Journal of Comparative Neurology·Jason P BrownH Georg Kuhn
Oct 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Christine T EkdahlOlle Lindvall
Nov 15, 2003·Science·Michelle L MonjeTheo D Palmer
Mar 30, 2004·Brain : a Journal of Neurology·G C DeLucaM M Esiri
Mar 30, 2004·Journal of Neuroscience Research·Phuong B TranRichard J Miller
Apr 14, 2004·Journal of Neuroscience Research·Helen K C YangFrancis G Szele
Jan 5, 2005·Nature Reviews. Cancer·Fu-Tong Liu, Gabriel A Rabinovich
Mar 21, 2006·Acta Neuropathologica·Maria Diaz-SanchezMargaret M Esiri
Mar 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Abdelhak BelmadaniRichard J Miller
Apr 28, 2006·Acta Neurologica Scandinavica. Supplementum·L BöP van der Valk
Jul 28, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bénédicte MennArturo Alvarez-Buylla
Aug 22, 2006·Brain : a Journal of Neurology·Peter PatrikiosHans Lassmann
Sep 13, 2006·Journal of Neurovirology·William J KarpusNicholas W Lukacs
Dec 22, 2006·The Journal of Comparative Neurology·Phuong B TranRichard J Miller
Dec 28, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yi-Ping YanRobert J Dempsey
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Brahim Nait-OumesmarAnne Baron-Van Evercooren
Sep 14, 2007·The Journal of Comparative Neurology·Sang Chae NamFrancis G Szele
Dec 22, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Marianna PapaspyridonosDavid R Greaves
Oct 17, 2008·Journal of Neuroinflammation·Gwendolyn E GoingsFrancis G Szele
Jan 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hui-Rong JiangMiodrag L Lukic
Apr 1, 2009·Molecular and Cellular Neurosciences·Renee J GordonBronwen Connor
Oct 3, 2009·Annals of Neurology·Stefano PluchinoGianvito Martino
Apr 8, 2010·Critical Reviews in Immunology·Thomas E Lane, Martin P Hosking
Apr 8, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tongguang WangAvindra Nath
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kunlin JinDavid A Greenberg
Apr 27, 2010·Nature Neuroscience·Beata JablonskaVittorio Gallo
Aug 24, 2010·Journal of Neuroimmunology·Bassem YamoutAli Bazarbachi
Oct 29, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sae-Bom JeonEun Jung Park
Nov 4, 2010·Cell Adhesion & Migration·Noelia Martinez-MolinaFrancis G Szele
Apr 20, 2011·Neuropathology and Applied Neurobiology·M StancicW Baron
Jun 23, 2011·Journal of Cell Science·Isabelle ComteFrancis G Szele

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Citations

Aug 24, 2016·Journal of Neuroinflammation·James M HillisFrancis G Szele
Jun 25, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Hideaki NishiharaTakashi Kanda
Jun 6, 2018·Frontiers in Molecular Neuroscience·Jian Jing Siew, Yijuang Chern
Oct 19, 2019·Glia·Osama Al-DalahmahFrancis G Szele
May 28, 2020·Biomolecules·Ivan SrejovicGvozden Rosic
May 23, 2020·Stem Cells·Osama Al-DalahmahFrancis G Szele
May 30, 2017·Frontiers in Cell and Developmental Biology·Linda OttoboniGianvito Martino
Sep 28, 2018·Frontiers in Cellular Neuroscience·Laura Thomas, Laura Andrea Pasquini
Apr 10, 2019·Neural Regeneration Research·Laura Thomas, Laura Andrea Pasquini
Aug 17, 2018·BioMed Research International·Ankit TandonRajnish Kumar Chaturvedi
Apr 21, 2020·Canadian Journal of Physiology and Pharmacology·Jingang SunLianghua Chen

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