Loss of H2Bub1 Expression is Linked to Poor Prognosis in Nodal Negative Colorectal Cancers

Pathology Oncology Research : POR
Nathaniel MellingAndreas H Marx

Abstract

To correlate H2Bub1 expression with outcome in colorectal cancer, H2Bub1 expression was analyzed by immunohistochemistry on a tissue microarray containing 1800 colorectal cancers. Results were compared to clinicopathological parameters.H2Bub1 IHC was seen in 1256 (79.3%) of 1584 interpretable CRC and was considered weak in 26.2% and strong in 53.1% of cancers. H2Bub1 expression was completely lost in 20.7% of the cases. Loss of H2Bub1 expression was associated with high tumor grade (p = 0.0211), high tumor stage (p = 0.0003), positive nodal status (p = 0.0139) and histological tumor type (p = 0.0202). No link was found between H2Bub1 expression and tumor localization (p = 0.1262), peritumoral lymphocytic infiltration (p = 0.2523) or vascular invasion (p = 0.5970).Loss of H2Bub1 expression in CRC was strongly associated with poor patient survival (p = 0.0006). This observation held true also in a subset survival analysis of nodal negative (N0) and nodal positive (N1) cancers (p = 0.0296 and p = 0.0197, respectively). In the subgroup of p53 negative cancers no prognostic impact of H2Bub1 staining was seen (p = 0.1924), whereas in p53 positive CRC H2Bub1 expression loss was associated with poor prognosis (p = 0.0031). Strikingly w...Continue Reading

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Citations

Nov 2, 2016·Nucleic Acids Research·Matthew R Northam, Kelly M Trujillo
Oct 16, 2018·Journal of Crohn's & Colitis·Robyn Laura KosinskySteven A Johnsen
Sep 19, 2019·Cell Death and Differentiation·Robyn Laura KosinskySteven A Johnsen
Jul 4, 2019·Clinical Epigenetics·Deborah SchneiderRobyn Laura Kosinsky
Mar 10, 2021·Bulletin du cancer·Sa ZhouTongcun Zhang
Jun 6, 2021·Cell Death and Differentiation·Robyn Laura KosinskySteven A Johnsen

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