Loss of heterozygosity analysis of a candidate gastric carcinoma tumor suppressor locus at 7q31

Cancer Genetics and Cytogenetics
Jianchuan XiaYi-Xing Zeng

Abstract

Gastric carcinoma is one of the most common malignancies in Asia. Although the allelic deletion of 7q has been reportedly associated with primary gastric carcinoma tumorigenesis, no predisposing genes in this region have been identified so far. Here, we report the results of genotype and loss of heterozygosity (LOH) analysis on 7q in this tumor. A panel of nine microsatellite markers distributed over the whole chromosome 7q was used for genotyping primary gastric carcinomas. Of 72 primary tumors LOH of D7S486 occurred in 24.0% (12/50) of cases. Fine mapping with 12 additional markers flanking D7S486 resulted in LOH of 30.36% (17/56) and defined one minimal deleted region in primary gastric carcinomas, a 90-kilobase region bounded by D7S2543 and D7S486 at 7q31.2. The allelic deletion correlates statistically with clinicopathologic variables. Our data suggest a possible link between putative tumor suppressor genes and gastric carcinoma in the 7q31 region.

References

Nov 30, 1992·Biochemical and Biophysical Research Communications·H KuniyasuE Tahara
Jan 1, 1992·Cancer Genetics and Cytogenetics·S XiaoP Li
Dec 1, 1994·International Journal of Cancer. Journal International Du Cancer·H KuniyasuE Tahara
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·J C ZenklusenC J Conti
Jan 1, 1993·Journal of Cancer Research and Clinical Oncology·E Tahara
Nov 1, 1995·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·A LatilR Lidereau
Jul 9, 1999·Genes, Chromosomes & Cancer·S TosiL Kearney
Feb 15, 2001·The Prostate·J CuiA R Brothman
Nov 12, 2002·Surgical Oncology Clinics of North America·Yuichi KasakuraJaffer Ajani
Nov 26, 2003·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Brenda C Y LiS C Sydney Chung
Apr 7, 2004·Cancer Genetics and Cytogenetics·M Belén GonzálezJesús M Hernández
May 22, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tamotsu SugaiMasanori Terashima
Oct 6, 2005·Experimental and Molecular Pathology·Hyun-Ah KimRyung-Ah Lee

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