Loss of heterozygosity in chromosomal region 16q24.3 associated with progression of prostate cancer

The Prostate
Päivi HärkönenPirkko Vihko

Abstract

The molecular mechanisms underlying the development and progression of prostate cancer have remained poorly understood. To find out potential genetic markers likely to underlie tumor progression, the pattern of allelic loss on chromosome arm 16q in matched primary, locally recurrent, and metastatic prostate cancer specimens was analyzed in the present study. The frequency of loss of heterozygosity (LOH) in 74 tumor specimens (62 primary cancer foci and 12 metastatic tumors) collected from 33 prostate cancer patients was determined by fragment analysis using 17 polymorphic microsatellite markers. The overall frequency of patients showing allelic loss at one or more loci on 16q was 68% (21/31) in primary tumors and 90% (28/31) in recurrent tumors. Of the individual markers, D16S520, locating in region 16q24.3, exhibited a statistically significant development of LOH during disease recurrence (P < 0.01). Regarding distant metastases, instead, there seemed to be no allelic loss events exclusively typical of metastatic tumors at 16q. The data suggest the location of gene(s) related to prostate cancer progression at 16q24.3.

References

Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B S CarterW B Isaacs
Aug 17, 1989·The New England Journal of Medicine·E D CrawfordP J Goodman
Jan 18, 1980·JAMA : the Journal of the American Medical Association·F K MostofiR E Stowell
Jul 17, 1998·The American Journal of Pathology·N N NupponenT Visakorpi
Sep 16, 1998·Human Genetics·M SatoA Horii
Feb 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Päivi HärkönenPirkko Vihko

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Citations

Jan 1, 2008·Forensic Science, Medicine, and Pathology·Karen Page, Eleanor A M Graham
Jun 15, 2007·Pharmacogenomics·Franca D'AmicoGiuseppe Novelli
May 27, 2015·International Journal of Cancer. Journal International Du Cancer·Martina KluthThorsten Schlomm
Sep 18, 2015·Journal of the National Cancer Institute·Milica PavlovicRoger R Gomis
Jul 11, 2006·Critical Reviews in Oncology/hematology·Mukesh Verma, Upender Manne
Sep 15, 2017·International Journal of Cancer. Journal International Du Cancer·Jia LiuAnnie L M Cheung
Jan 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·Srinadh ChopparaManas Kumar Santra
Jul 15, 2005·The Prostate·Gaëlle FromontOlivier Cussenot
May 26, 2017·Cancer Medicine·Jinyuan MaChunying Li
Mar 21, 2018·Oncology Letters·Yuyong TanJirong Huo
Nov 29, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Éric LévesqueChantal Guillemette

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