Loss of heterozygosity in thyroid hormone receptor beta in invasive breast cancer

Tumori
Yaqin LingYong Wang

Abstract

Loss of heterozygosity (LOH) on chromosome arm 3p, where the gene of thyroid hormone receptor beta (THRB) is located, has been reported in breast cancer. Although some studies performed in vitro have suggested that THRB could act as a tumor suppressor in breast cancer development, there is still no unequivocal evidence to support this. To determine the role of LOH in breast tumor development, the LOH of THRB and its proximal microsatellite markers D3S1293, D3S3659, D3S3700, D3S2307 and D3S2336 was investigated in a genomic region spanning ~3.3 Mb in tumor specimens and in corresponding normal tissues of 74 invasive breast cancer patients. The association was analyzed between LOH in microsatellite markers and clinicopathological characteristics. LOH was detected in D3S1293 (36.7%), THRB (59.4%), D3S3659 (37.5%) and D3S3700 (55.2%) among the informative cases, while LOH was not detected in D3S2307 and D3S2336. Cases exhibited LOH of 52.8%-71.4% if any 2 markers were combined and analyzed out of the first 4 microsatellite markers. LOH in THRB was associated with negative estrogen receptor (ER), negative progesterone receptor (PR), both negative estrogen receptor and progesterone receptor (HR) and human epidermal growth factor rece...Continue Reading

References

Aug 31, 2002·Journal of Human Genetics·Qifeng YangKennichi Kakudo
Apr 2, 2003·Cancer Letters·José M González-SanchoAlberto Muñoz
Jul 29, 2005·International Journal of Cancer. Journal International Du Cancer·Eriko TokunagaYoshihiko Maehara
Jan 31, 2006·Molecular and Cellular Endocrinology·Paul M YenXianmin Xia
Oct 14, 2006·The Journal of Clinical Investigation·Hao YingSheue-Yann Cheng
Jan 6, 2007·International Journal of Cancer. Journal International Du Cancer·Heidi SchwarzenbachKlaus Pantel
Mar 14, 2008·BJU International·Heidi SchwarzenbachMartin G Friedrich
Jul 31, 2009·PloS One·Olaia Martínez-IglesiasAna Aranda
Sep 1, 2009·Trends in Endocrinology and Metabolism : TEM·Ana ArandaAlberto Zambrano
Mar 31, 2012·Arquivos brasileiros de endocrinologia e metabologia·Letícia Schwerz WeinertAna Luiza Maia
Apr 17, 2012·Human Pathology·Márcia Maria Costa de OliveiraIglenir João Cavalli
Apr 18, 2012·Biochimica Et Biophysica Acta·Won Gu Kim, Sheue-yann Cheng
May 4, 2013·Virchows Archiv : an International Journal of Pathology·Guillaume GauchotteJean-Michel Vignaud
Apr 12, 2014·Hormones : International Journal of Endocrinology and Metabolism·Antonio J AmorJosep Oriola

❮ Previous
Next ❯

Citations

Apr 1, 2017·Applied Immunohistochemistry & Molecular Morphology : AIMM·S-Maryam SeyedolmohadessinGholamreza Pourmand

❮ Previous
Next ❯

Datasets Mentioned

BETA
D3S2336

Methods Mentioned

BETA
PCR
electrophoresis
xenografting
ubiquitination

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.