PMID: 7539286Apr 1, 1995Paper

Loss of heterozygosity on 7q31 occurs early during breast tumorigenesis

Genes, Chromosomes & Cancer
M H ChampèmeR Lidereau

Abstract

Although human breast tumorigenesis is associated with the accumulation of mutations both in oncogenes and in tumor suppressor genes, the identity of the genetic alterations that are critical in the early stages of the breast tumorigenic process remains obscure. A high frequency (27-41%) of loss of heterozygosity (LOH) occurrence has been shown at the MET locus on chromosome band 7q31 and this specific alteration is associated with poorer survival. Here, we report that restriction fragment length polymorphism (RFLP) analysis on 221 informative (heterozygous) primary breast tumors and 57 informative relapses (13 local recurrences and 44 distant metastases) revealed a similar frequency of 7q31 LOH as tumors progress from primary cancer to relapse, in marked contrast to other changes such as 11p15.5 LOH. This finding suggests that inactivation of a putative tumor suppressor gene located in 7q31 is a very early event in breast tumorigenesis. Our results also show that metastatic potential is an induced phenomenon that occurs at a relatively early stage, rather than a marker of tumor progression.

References

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Citations

Jan 1, 1996·Pathology Oncology Research : POR·Marianna SztánEdith Oláh
Aug 26, 2000·Cancer Genetics and Cytogenetics·P H TanY Chong
May 4, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·T SauerO Naess
Oct 18, 2005·Annals of Surgical Oncology·Rachel E EllsworthCraig D Shriver
Aug 17, 1999·Seminars in Cancer Biology·S Ingvarsson
Aug 1, 1998·Japanese Journal of Cancer Research : Gann·K KuroseM Emi
Jun 21, 2019·Cytogenetic and Genome Research·Hirohisa HiraiAnthony J Tosi
Dec 1, 1995·Genes, Chromosomes & Cancer·I Bièche, R Lidereau
Aug 14, 1999·International Journal of Cancer. Journal International Du Cancer·I ZborovskayaR Lidereau

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