PMID: 7529042Sep 1, 1994Paper

Loss of heterozygosity on the short arm of chromosome 3 in mesothelioma cell lines and solid tumors

Genes, Chromosomes & Cancer
M A ZeigerH I Pass

Abstract

Cytogenetic analysis of mesothelioma cell lines and solid tumors has documented non-random chromosomal abnormalities on the short arm of chromosome 3 from 3p14 to 3p25. We therefore examined nine mesothelioma cell lines, their corresponding tumors, and 15 additional mesothelioma tumors for loss of heterozygosity on 3p from 3p13 to 3p25.5 by polymerase chain reaction and restriction fragment length polymorphism analysis at 8 loci: D3S3, D3S30, D3S6, D3S2, D3S32, D3F15S2, THRB, and VHL. Loss of heterozygosity was documented by loss of one of two alleles in the tumor DNA whose corresponding normal DNA was heterozygous and was documented in four of nine mesothelioma cell lines and six of 15 mesothelioma tumors or a total of 42% of the mesotheliomas evaluated. This study suggests the involvement of a gene on the short arm of chromosome 3 in the development of mesotheliomas.

References

Jun 21, 1989·Journal of the National Cancer Institute·J RobozL Szrajer
Jul 15, 1988·Cancer Genetics and Cytogenetics·M TiainenS Knuutila
Feb 15, 1986·Cancer Genetics and Cytogenetics·Z GibasA A Sandberg

❮ Previous
Next ❯

Citations

Apr 12, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·Berrin TuncaIlker Ercan
Jan 1, 1995·Pathology Oncology Research : POR·Xiang Gao, Kenneth V Honn
Jun 27, 2001·Cancer Genetics and Cytogenetics·A A Sandberg, J A Bridge
Jun 27, 2000·Cancer Genetics and Cytogenetics·B TuncaA Kizil
Feb 1, 1997·Critical Reviews in Oncology/hematology·H C HoogstedenT van Gelder
Apr 4, 2013·Nature Reviews. Cancer·Michele CarboneGiovanni Gaudino
Dec 24, 1997·Environmental Health Perspectives·J F LechnerB I Gerwin
Sep 10, 2005·Expert Review of Molecular Diagnostics·Saul Suster, Cesar Moran
Jan 5, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·M KaradağO Gözü
Sep 13, 2006·Cancer Genetics and Cytogenetics·Marina MustiSakari Knuutila
Apr 19, 2012·Biochemical and Biophysical Research Communications·Sara Castiglioni, Jeanette A M Maier
Nov 12, 2016·Proceedings of the National Academy of Sciences of the United States of America·Yoshie YoshikawaMichele Carbone
May 1, 1994·Nature Genetics·J R GnarraF M Duh
Dec 10, 1999·British Journal of Cancer·A M BjörkqvistS Knuutila
Apr 12, 2020·International Journal of Cancer. Journal International Du Cancer·Moonsun JungMichelle J Henderson
Nov 5, 1997·International Journal of Cancer. Journal International Du Cancer·Y J ChenJ G Chang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.