PMID: 7547630Aug 1, 1995Paper

Loss of heterozygosity on the X chromosome in human breast cancer

Genes, Chromosomes & Cancer
M L LoupartJ Varley

Abstract

The analysis of loss of heterozygosity (LOH) in tumours can be a powerful tool for mapping the sites of tumour suppressor genes in the human genome. A panel of breast cancer patients was assembled as pairs of tumour and lymphocyte DNA samples and LOH studies carried out by Southern hybridisation with polymorphic loci mapping to the X chromosome with appropriate controls. Deletion mapping revealed a high frequency of small regionalised deletions, defining at least three independent regions, one of which is particularly well mapped to a 500 kb stretch of DNA in the distal portion of the pseudoautosomal region of Xp. A second region has been identified within the pseudoautosomal region close to the pseudoautosomal boundary, and there is a third discrete site of loss on distal Xq. Perturbations of sequences at these regions represent independent events in a number of patients. This study represents the first detailed analysis of LOH on the X chromosome in human breast tumours, the results of which indicate that at least three regions of this chromosome are involved in the disease.

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Citations

Sep 9, 2008·Breast Cancer Research and Treatment·Yuan SunD Joshua Liao
Jul 20, 2002·Cancer Genetics and Cytogenetics·Laura RoncuzziAnna Gasperi-Campani
Feb 11, 2010·Science Signaling·Hsu-Ping KuoMien-Chie Hung
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Apr 21, 2012·Future Oncology·Runhua LiuLizhong Wang
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Jan 1, 2010·The American Journal of Pathology·Gaëlle GendronneauLucie Jeannotte
Oct 23, 1997·Genes, Chromosomes & Cancer·J S MorrisP A Edwards
Nov 22, 2019·The EMBO Journal·Marie DumontDaniele Fachinetti
Feb 11, 2020·Cellular and Molecular Life Sciences : CMLS·Dan WangCan Guo
Jan 1, 1997·Hereditas·L R CavalliS R Rogatto

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