Loss of heterozygosity studies indicate that chromosome arm 1p harbors a tumor supressor gene for renal oncocytomas

Genes, Chromosomes & Cancer
C A Thrash-BinghamK D Tartof

Abstract

We carried out a complete genome scan for loss of heterozygosity (LOH) in four renal oncocytomas by using highly polymorphic CA repeat microsatellite loci. Three of the four tumors exhibited LOH for chromosome arm 1p, and the oncocytomas of both female patients lost Xq. Therefore, these chromosome arms may harbor tumor suppressor genes involved in the etiology of this disease. Although the genomes of ontocytomas are relatively stable, two different microsatellite loci in one tumor were mutated by + or - 2 nt. Similar alterations in CA repeats that are probably due to spontaneous mutation have been observed in renal cell carcinomas.

References

Aug 1, 1992·The Journal of Urology·A M MeloniA A Sandberg
Jan 1, 1992·Genes, Chromosomes & Cancer·S M DobinV O Speights
Jul 1, 1992·Cancer Genetics and Cytogenetics·A M MeloniR D White
Jul 1, 1989·The Journal of Urology·T A WalterA A Sandberg
Mar 1, 1988·The Journal of Urology·K E PsihramisA A Sandberg
Aug 1, 1988·Cancer Genetics and Cytogenetics·J MilesD J Weaver
Jun 15, 1987·Cancer·G KovacsW De Riese
Oct 1, 1986·The Journal of Urology·K E PsihramisA A Sandberg
Apr 1, 1981·The Journal of Urology·M M LieberG M Farrow
May 1, 1995·Genes, Chromosomes & Cancer·V L CrynsA Arnold
Jun 1, 1994·Nature Genetics·G GyapayJ Weissenbach
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·C A Thrash-BinghamK D Tartof
Aug 1, 1993·Human Molecular Genetics·J L Weber, C Wong
Sep 1, 1962·Cancer·H HAMPERL

❮ Previous
Next ❯

Citations

Dec 6, 1997·International Journal of Cancer. Journal International Du Cancer·T DijkhuizenB de Jong
Oct 26, 2005·Virchows Archiv : an International Journal of Pathology·Cinzia AzzoniCesare Bordi
Apr 21, 2012·Future Oncology·Runhua LiuLizhong Wang
Oct 10, 2003·Cancer Investigation·Dezhong Joshua LiaoFazlul H Sarkar
Sep 17, 1999·The American Journal of Pathology·S KnuutilaY Zhu
Jul 2, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Maria V Yusenko
Jan 10, 2004·The Journal of Urology·Valerie LindgrenMaria M Picken
Jun 15, 2004·Cancer Genetics and Cytogenetics·Tahseen Al-SaleemRobert G Uzzo
Dec 13, 2005·Cancer Genetics and Cytogenetics·Marta SalidoFrancesc Solé
Oct 31, 2002·American Journal of Medical Genetics·Aurelia M Meloni-Ehrig
Feb 11, 2020·Cellular and Molecular Life Sciences : CMLS·Dan WangCan Guo
May 7, 2002·Urology·Debby H ChaoArie S Belldegrun
Oct 27, 2004·Archives of Pathology & Laboratory Medicine·Valerie LindgrenMaria M Picken

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
J TakitaJ Yokota
© 2021 Meta ULC. All rights reserved