PMID: 7542423Jan 1, 1995Paper

Loss of hilar somatostatin neurons following tetanus toxin-induced seizures

Acta Neuropathologica
J MitchellL E Sundstrom

Abstract

A loss of inhibitory interneurons has been reported in the hippocampus following seizure activity in various animal models of epilepsy and in human epileptic tissue. The question of whether particular populations of inhibitory neurons are similarly affected by the chronic block of inhibition that results after tetanus toxin injections directly into the brain has not previously been addressed. In the present study a unilateral intrahippocampal injection of tetanus toxin into the ventral hippocampus was used to produce a chronic epileptic syndrome characterised by brief seizures that recurred intermittently for 6-8 weeks. The results reveal, for the first time, the morphological changes in somatostatin interneurons following tetanus toxin-induced seizures in the rat. A bilateral short-term increase in immunoreactivity of somatostatin neurons is present 1 week after injection. This is accompanied by an increased intensity of somatostatin-immunoreactive axon terminals in the outer molecular layer of the dentate gyrus, which is more marked on the contralateral side. A chronic and significant loss of somatostatin-immunoreactive neurons was noted in the hilus of the dentate gyrus 2 months later. The significance of the chronic loss of...Continue Reading

References

Jan 1, 1975·International Review of Neurobiology·B S Meldrum
Apr 1, 1977·Journal of Neurology, Neurosurgery, and Psychiatry·J MellanbyP Thompson
Jan 1, 1990·Advances in Experimental Medicine and Biology·A RepresaY Ben-Ari
Nov 27, 1990·Neuroscience Letters·J A ShawJ Mellanby
Sep 1, 1989·Annals of Neurology·T SutulaL Ramirez
Aug 28, 1989·Brain Research·N C de LanerolleD D Spencer
Mar 30, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·B HenselH H Wellhöner
Oct 1, 1981·Journal of Neurochemistry·G L CollingridgeJ Mellanby

❮ Previous
Next ❯

Citations

Mar 1, 1997·Acta histochemica·S PretelD Piekut
Feb 2, 2002·Epilepsy Research·Paul S BuckmasterMalcolm J Low
Oct 7, 1998·Epilepsy Research·J G Jefferys, R D Traub
Dec 3, 1999·The European Journal of Neuroscience·A Vezzani, D Hoyer
Apr 20, 2010·Brain : a Journal of Neurology·Premysl JiruskaJohn G R Jefferys
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J BengzonO Lindvall
Oct 18, 2012·Neuromolecular Medicine·Fabio GualtieriGiuseppe Biagini
May 12, 2015·Journal of Neuroscience Methods·John JefferysPeter Bedner
Jan 6, 2007·The Journal of Physiology·Li-Ying Fu, Anthony N van den Pol
Oct 19, 2007·Molecular and Cellular Endocrinology·V A S H DalmS W J Lamberts
Jul 30, 2008·The European Journal of Neuroscience·Virág T TakácsAttila I Gulyás
Sep 22, 2006·The European Journal of Neuroscience·Lucia WittnerGyörgy Buzsáki
Oct 18, 2014·Frontiers in Neuroanatomy·Kinga Tóth, Zsófia Maglóczky
Apr 29, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J Mitchell
Mar 29, 2002·The Journal of Comparative Neurology·Paul S BuckmasterGuo Feng Zhang
Apr 14, 1999·Journal of Neurophysiology·M K Tallent, G R Siggins

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.