Loss of hIRH mRNA expression from premalignant adenomas and malignant cell lines

Biochemical and Biophysical Research Communications
N A BegumG F Barnard

Abstract

We recently isolated from differential displays and subsequently cloned a human alpha-intercrine (hIRH) whose mRNA is reduced in human hepatocellular carcinomas. We now report that on Northern blots its mRNA is absent from premalignant colonic adenomas and from all of 27 human malignant cell lines (including breast, cervix, colon, duodenal, gastric, leukemia, liver, lung, melanoma, and pancreatic lines). hIRH mRNA was present in most normal human and mouse tissues and fibroblast derived cell lines but absent from leukocytes and brain. Two mRNA signals, at approximately 2 Kb and approximately 3.5 Kb, had variation in signal strength or size between tissues and species.

Citations

Jul 10, 2003·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Rosalba Salcedo, Joost J Oppenheim
Mar 14, 2016·Clinical & Experimental Metastasis·Suresh Singh YadavGopeshwar Narayan
May 15, 2003·International Reviews of Immunology·Mark S Brault, Robert A Kurt
Apr 16, 2002·British Journal of Cancer·A J SchraderJ Lauber
Jul 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K ShimodaG F Barnard
Nov 30, 2000·The American Journal of Gastroenterology·T KatsutaG F Barnard
Dec 16, 1997·International Journal of Cancer. Journal International Du Cancer·K ShibutaG F Barnard

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