Loss of histaminergic modulation of thermoregulation and energy homeostasis in obese mice.

Neuroscience
Jasmine SethiIustin Tabarean

Abstract

Histamine acts centrally to increase energy expenditure and reduce body weight by mechanisms not fully understood. It has been suggested that in the obese state hypothalamic histamine signaling is altered. Previous studies have also shown that histamine acting in the preoptic area controls thermoregulation. We aimed to study the influence of preoptic histamine on body temperature and energy homeostasis in control and obese mice. Activating histamine receptors in the preoptic area by increasing the concentration of endogenous histamine or by local injection of specific agonists induced an elevation of core body temperature and decreased respiratory exchange ratio (RER). In addition, the food intake was significantly decreased. The hyperthermic effect was associated with a rapid increase in mRNA expression of uncoupling proteins in thermogenic tissues, the most pronounced being that of uncoupling protein (UCP) 1 in brown adipose tissue and of UCP2 in white adipose tissue. In diet-induced obese mice histamine had much diminished hyperthermic effects as well as reduced effect on RER. Similarly, the ability of preoptic histamine signaling to increase the expression of uncoupling proteins was abolished. We also found that the express...Continue Reading

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Citations

Aug 31, 2013·Reviews in Endocrine & Metabolic Disorders·Liangyou Rui
Feb 20, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jiamei LianChao Deng
Nov 27, 2015·The Journal of Pharmacology and Experimental Therapeutics·Jesse Lea CarlinMarc L Reitman
Aug 25, 2015·Neuropharmacology·Roberto De LucaOlga A Sergeeva
Jun 25, 2015·Neuropharmacology·Iustin V Tabarean
Jun 10, 2008·Neurotoxicology·Randall T PetersonToshio Narahashi
Oct 30, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Maximiliano Rapanelli
May 31, 2018·American Journal of Physiology. Endocrinology and Metabolism·Shalini JainMarc L Reitman
Jan 11, 2020·Frontiers in Oncology·Hannes ZwicklMartin Pecherstorfer

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