Loss of hsp70.1 Decreases Functional Motor Recovery after Spinal Cord Injury in Mice.

The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Hyun Jeong KimJunesun Kim

Abstract

Heat shock proteins (HSPs) are specifically induced by various forms of stress. Hsp70.1, a member of the hsp70 family is known to play an important role in cytoprotection from stressful insults. However, the functional role of Hsp70 in motor function after spinal cord injury (SCI) is still unclear. To study the role of hsp70.1 in motor recovery following SCI, we assessed locomotor function in hsp70.1 knockout (KO) mice and their wild-type (WT) mice via the Basso, Beattie and Bresnahan (BBB) locomotor rating scale, before and after spinal hemisection at T13 level. We also examined lesion size in the spinal cord using Luxol fast blue/cresyl violet staining. One day after injury, KO and WT mice showed no significant difference in the motor function due to complete paralysis following spinal hemisection. However, when it compared to WT mice, KO mice had significantly delayed and decreased functional outcomes from 4 days up to 21 days after SCI. KO mice also showed significantly greater lesion size in the spinal cord than WT mice showed at 21 days after spinal hemisection. These results suggest that Hsp70 has a protective effect against traumatic SCI and the manipulation of the hsp70.1 gene may help improve the recovery of motor fun...Continue Reading

References

Jan 1, 1992·Journal of Neurosurgery·E D Hall
Feb 1, 1995·Journal of Neurotrauma·D M BassoJ C Bresnahan
Jun 4, 1998·Biochemical and Biophysical Research Communications·Y FukamachiK Higashi
Oct 14, 1998·Progress in Neurobiology·Y Taoka, K Okajima
Nov 24, 1999·The American Journal of Physiology·M WagnerC J Kirkpatrick
Dec 6, 2000·Progress in Brain Research·J R Bethea
Nov 28, 2001·Journal of Neurochemistry·G SongV L Rao
Jul 19, 2002·Journal of Neuroscience Research·Seiji KikuchiKunio Tashiro
Mar 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David P StirlingWolfram Tetzlaff
Apr 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Denis GrisLynne C Weaver
Jul 10, 2004·Stroke; a Journal of Cerebral Circulation·Seung-Hoon LeeByung-Woo Yoon
Jul 13, 2004·The Spine Journal : Official Journal of the North American Spine Society·Brian K KwonAlexander R Vaccaro
May 18, 2005·Neuroscience Letters·Susanne KunzEllen Niederberger
Sep 1, 2005·Journal of Neuroscience Research·Eric Anthony SribnickNaren Lal Banik
Oct 21, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mac B RobinsonCarol E Milligan
Aug 12, 2006·Journal of Neuroscience Research·Eric Anthony SribnickNaren Lal Banik
Apr 25, 2007·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Yoon Cheol ShinWon Gon Kim
Aug 19, 2007·Inflammation & Allergy Drug Targets·Yu ChenR William Currie
Mar 17, 2009·European Journal of Pharmacology·Mitsuo TanabeHideki Ono

❮ Previous
Next ❯

Citations

Apr 23, 2013·Brain Research·Hai WenFeng Zhang
May 31, 2011·Veterinary Parasitology·Zhancheng TianJin Luo
Nov 6, 2014·Surgical Neurology International·Victoria TrinhMuhammad O Chohan
Mar 17, 2020·Journal of Neurochemistry·Rafaela Silva Dos SantosGiovane Galdino
Jul 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fatemeh AbbaszadehHaroon Khan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.