Abstract
Invasive nontyphoidalSalmonella(iNTS) infections are commonly associated withPlasmodium falciparuminfections, but the immunologic basis for this linkage is poorly understood. We hypothesized thatP. falciparuminfection compromises the humoral and cellular immunity of the host to NTS, which increases the susceptibility of the host to iNTS infection. We prospectively recruited children aged between 6 and 60 months at a Community Health Centre in Blantyre, Malawi, and allocated them to the following groups; febrile with uncomplicated malaria, febrile malaria negative, and nonfebrile malaria negative. Levels ofSalmonella entericaserovar Typhimurium-specific serum bactericidal activity (SBA) and whole-blood bactericidal activity (WBBA), complement C3 deposition, and neutrophil respiratory burst activity (NRBA) were measured. Levels of SBA with respect toSTyphimurium were reduced in febrileP. falciparum-infected children (median, -0.20 log10 [interquartile range {IQR}, -1.85, 0.32]) compared to nonfebrile malaria-negative children (median, -1.42 log10 [IQR, -2.0, -0.47],P= 0.052). In relation to SBA, C3 deposition onSTyphimurium was significantly reduced in febrileP. falciparum-infected children (median, 7.5% [IQR, 4.1, 15.0]) compare...Continue Reading
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