Abstract
We previously have reported that ICP22, an immediate early gene of herpes simplex virus type 1 (HSV-1), binds to the CD80 promoter to suppress CD80 expression in antigen-presenting cells, leading to reduced T-cell function and protection. In contrast, overexpression of CD80 exacerbates corneal scarring (CS) in ocularly infected mice. In this study we tested the hypothesis that the absence of ICP22 could increase disease severity. To test our hypothesis, BALB/c mice were ocularly infected after corneal scarification with a recombinant HSV-1 lacking the ICP22 gene with its parental wild-type (WT) virus (KOS) as a control. Virus replication in the eye, CS, angiogenesis, latency, and reactivation between ICP22 null virus and WT KOS were determined. In addition, expression of IL-2, IL-4, IFN-γ, IFN-α, granzyme A, granzyme B, and perforin by CD4 and CD8 T cells in corneas of infected mice on days 3, 5, 7, 10, 14, 21, and 28 postinfection were determined by flow cytometry. We found similar levels of eye disease and angiogenesis in mice following corneal scarification and ocular infection with the ICP22 null virus or parental WT virus despite reduced virus replication in the eye and reduced latency and reactivation in mice ocularly inf...Continue Reading
References
Nov 1, 1988·Journal of Virology·S L WechslerH Ghiasi
Dec 1, 1988·The Journal of General Virology·S L WechslerH Ghiasi
Aug 1, 1985·Journal of Virology·A E SearsB Roizman
Jan 1, 1994·Archives of Virology·K L PoffenbergerR C Herman
Nov 1, 1996·The British Journal of Ophthalmology·K R WilhelmusP A Asbell
Mar 1, 1997·Immunity·F BorrielloA H Sharpe
Feb 24, 2001·Cornea·T J Liesegang
Mar 26, 2002·Nature Reviews. Immunology·Arlene H Sharpe, Gordon J Freeman
Mar 26, 2002·Immunity·Sunil S MetkarChristopher J Froelich
Oct 3, 2002·Nature Reviews. Immunology·Joseph A Trapani, Mark J Smyth
May 27, 2003·Investigative Ophthalmology & Visual Science·Curtis R BrandtJamie J Van Gompel
Oct 2, 2003·Sexually Transmitted Diseases·Craig M RobertsScott J Spear
Oct 28, 2003·Investigative Ophthalmology & Visual Science·Curtis R Brandt, Aaron W Kolb
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susmit SuvasBarry T Rouse
May 8, 2004·Seminars in Immunology·Edward M BertramTania H Watts
Jan 26, 2005·Sexually Transmitted Diseases·Ameeta E SinghJutta K Preiksaitis
Feb 3, 2005·Seminars in Pediatric Infectious Diseases·Beth A AuslanderSusan L Rosenthal
Apr 29, 2005·Microbes and Infection·Partha S Biswas, Barry T Rouse
Oct 29, 2005·FEBS Letters·Her JunIn-Hak Choi
Nov 12, 2005·Current Eye Research·David M Koelle, Homayon Ghiasi
Dec 31, 2005·Nature·Daniel L BarberRafi Ahmed
Feb 17, 2007·Nature Immunology·Arlene H SharpeGordon J Freeman
Jul 17, 2007·Immunity·Manish J ButteGordon J Freeman
Sep 28, 2007·Journal of Virology·Kevin R MottHomayon Ghiasi
Jul 29, 2008·Microbes and Infection·Susmit SuvasBarry T Rouse
Aug 1, 2008·Journal of Virology·Kevin R MottHomayon Ghiasi
Dec 19, 2008·Journal of Virology·Kevin R MottHomayon Ghiasi
Jul 14, 2010·Biochemical Pharmacology·Patricia VandevenneJacques Piette
Feb 11, 2011·Journal of Virology·Sariah J AllenHomayon Ghiasi
Mar 8, 2013·Future Microbiology·Stephen A Rice, David J Davido
Sep 13, 2013·Annual Review of Microbiology·Bernard Roizman, Richard J Whitley
Oct 4, 2013·Journal of Virology·Heba H Mostafa, David J Davido
Jan 30, 2014·PloS One·Kevin R MottHomayon Ghiasi
Apr 4, 2014·PloS One·Kevin R MottHomayon Ghiasi
Mar 11, 2016·Journal of Virology·Kevin R MottHomayon Ghiasi
Aug 2, 2016·Immunology·Sarah DimeloeChristoph Hess
Apr 2, 2017·Journal of Neuroimmunology·Dane PhelanDavid C Bloom
Jul 18, 2017·PLoS Pathogens·Allison F ChristiaansenSteven M Varga
Apr 15, 2018·Proceedings of the National Academy of Sciences of the United States of America·Eunseon AhnRafi Ahmed
May 24, 2018·Nature Reviews. Immunology·Guillaume GaudPaul E Love
May 31, 2018·Microbes and Infection·Ujjaldeep JaggiBarry T Rouse
Oct 18, 2018·Cellular and Molecular Life Sciences : CMLS·Lulia KoujahDeepak Shukla
Nov 9, 2018·Journal of Virology·Harry Matundan, Homayon Ghiasi
Nov 18, 2018·F1000Research·Richard Whitley, Joel Baines
Citations
Feb 9, 2020·Advances in Therapy·Daniel ViriatoRobert E MacLaren
Dec 20, 2019·Journal of Virology·Ujjaldeep JaggiHomayon Ghiasi
Oct 18, 2019·Journal of Virology·Kati TormanenHomayon Ghiasi
Jun 10, 2020·Investigative Ophthalmology & Visual Science·Satoshi HiroseHomayon Ghiasi
Dec 31, 2020·Viruses·Christos DogrammatzisMaria Kalamvoki
May 21, 2021·Frontiers in Immunology·Luisa F DuartePablo A González
Jun 25, 2021·Frontiers in Microbiology·Ying WuAnchun Cheng
Jul 21, 2021·MBio·Harry H MatundanHomayon Ghiasi
Jul 22, 2021·Journal of Virology·Harry H MatundanHomayon Ghiasi
Oct 16, 2021·PLoS Pathogens·Ujjaldeep JaggiHomayon Ghiasi