Loss of inorganic ions from host cells infected with Chlamydia psittaci.

Infection and Immunity
G T Chang, J W Moulder

Abstract

Mouse fibroblasts (L cells) infected with the 6BC strain of Chlamydia psittaci released potassium ion (K(+)) into the extracellular milieu in a way that depended on size of inoculum and time after infection. When the multiplicity of infection was 500 to 1,000 50% infectious units (ID(50)) per L cell, loss of intracellular K(+) was first apparent 4 to 10 h after infection and was nearly complete at 6 to 20 h. Magnesium ion and inorganic phosphate (P(i)) were also released. Similar multiplicities of ultraviolet-inactivated C. psittaci also caused release of K(+). Leakage of inorganic ions probably resulted from immediate damage to the host-cell plasma membrane during ingestion of large numbers of chlamydiae. With multiplicities of 1 to 50 ID(50) per L cell, ingestion of C. psittaci was not by itself enough to cause release of K(+) and P(i) from infected L cells. There was a delay of 36 to 72 h between infection and massive leakage of intracellular ions during which time the chlamydiae multiplied extensively. Fifty ID(50) of ultraviolet-inactivated C. psittaci per L cell did not bring about significant leakage of K(+), even after 72 h. The mechanism whereby these multiplicities of infection destroy the ability of host cells to ret...Continue Reading

Citations

Aug 24, 1978·The New England Journal of Medicine·T W Chang, P Areson
Jul 16, 2008·The Journal of Cell Biology·Stefan A PaschenGeorg Häcker
Dec 19, 2001·Infection and Immunity·Jean-Luc PerfettiniDavid M Ojcius
Aug 31, 2006·Infection and Immunity·Songmin YingGeorg Häcker
Sep 21, 2004·Nature Reviews. Microbiology·Gerald I Byrne, David M Ojcius
Sep 9, 2020·FEMS Microbiology Reviews·Barbara S Sixt
Sep 1, 1982·Infection and Immunity·N J Levy, J W Moulder
Mar 1, 1991·Microbiological Reviews·J W Moulder

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