Loss of Med1/TRAP220 promotes the invasion and metastasis of human non-small-cell lung cancer cells by modulating the expression of metastasis-related genes

Cancer Letters
Hyun-Ju KimJeanho Yun

Abstract

Med1/TRAP220 is an essential component of the TRAP/Mediator complex. In this study, we present a novel function of Med1 in human non-small-cell lung cancer (NSCLC) progression. We found that the loss of Med1 expression was strongly associated with increased rates of invasion and metastasis in NSCLC patients. Consistent with lung cancer patient data, the knockdown of Med1 in NSCLC cell lines led to an increase in cell migration and invasion. Med1-depleted cells displayed an increase in metastasis in a xenograft tumor model and in an in vivo metastasis assay. Moreover, a microarray analysis revealed that the mRNA levels of the metastasis-related genes uPAR, ID2, ID4, PTP4A1, PKP3, TGM2, PLD1, TIMP2, RGS2, and HOXA4 were altered upon Med1 knockdown. Collectively, these results suggest that the loss of Med1 increases the invasive potential of human NSCLC cells by modulating the expression of metastasis-related genes.

References

Sep 9, 2000·Current Opinion in Cell Biology·K T PreissnerA E May
Feb 13, 2002·Oncogene·Raymond FradeMonique Barel
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kapil MehtaAysegul A Sahin
Aug 17, 2005·Cancer Research·Chiyuki FurukawaYusuke Nakamura
Mar 4, 2006·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Mar 17, 2006·Cancer Research·James J FiordalisiAdrienne D Cox
Apr 1, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hiu-Fung YuenKwok-Wah Chan
Apr 13, 2006·The Journal of Biological Chemistry·Jung Hwan KimSung Ho Ryu
Sep 27, 2008·Science·Christoph A Klein
Feb 27, 2009·International Journal of Cancer. Journal International Du Cancer·Jean de La Croix NdongRaymond Frade
Mar 14, 2009·Differentiation; Research in Biological Diversity·Takayo OtaNelly Auersperg
Mar 25, 2009·Nature Reviews. Cancer·Don X NguyenJoan Massagué
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yu Yang SoonMichael J Boyer
Jun 13, 2009·International Journal of Cancer. Journal International Du Cancer·Padmaja GadeDhananjaya V Kalvakolanu
Sep 3, 2009·Molecular Cancer Research : MCR·Christian KlausenNelly Auersperg
Sep 29, 2009·Nature Structural & Molecular Biology·Giulia FontemaggiGiovanni Blandino
Dec 23, 2009·Nature Reviews. Molecular Cell Biology·Harvey W Smith, Chris J Marshall
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Dong Woo KangDo Sik Min
Jul 24, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jeanho YunMee Sook Roh

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Citations

Jul 2, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Kyung A KwonHyo-Jin Kim
Mar 15, 2016·Acta Biochimica Et Biophysica Sinica·Minjee KimJeanho Yun
Sep 5, 2015·Interdisciplinary Sciences, Computational Life Sciences·Ruiqi MaJianzhen Xu
Dec 6, 2012·Biochemical and Biophysical Research Communications·Ae Jeong KimJeanho Yun
Dec 18, 2013·Biochimica Et Biophysica Acta·Concetta SchianoClaudio Napoli
Apr 13, 2015·Interdisciplinary Sciences, Computational Life Sciences·Ruiqi MaJianzhen Xu
May 30, 2013·Journal of Proteome Research·He-chun LinMing Yao
Jan 13, 2018·Acta Biochimica Et Biophysica Sinica·Young Yeon KimJeanho Yun
Apr 25, 2013·Nature Reviews. Cancer·Megan J BywaterRoss D Hannan
Aug 15, 2013·The Journal of Biological Chemistry·Navin ViswakarmaJanardan K Reddy
Nov 7, 2019·Journal of Cellular Biochemistry·Matthew R FemiaLizabeth A Allison
Apr 22, 2017·Acta Biochimica Et Biophysica Sinica·Hyun-Ju Kim, Jeanho Yun
Nov 7, 2019·Cell Death & Disease·Nadine H BrückmannMorten F Gjerstorff
Sep 26, 2020·Molecular Pharmacology·Harrison J McNabbBenita Sjögren
Mar 15, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kun WuLong Ma

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