Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.

Proceedings of the National Academy of Sciences of the United States of America
Sébastien S HébertBart De Strooper

Abstract

Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well established, fairly little is known about the molecular mechanisms affecting Abeta generation in sporadic AD. Deficiency in Abeta clearance is certainly a possibility, but increased expression of proteins like APP or BACE1/beta-secretase may also be associated with the disease. We therefore investigated changes in microRNA (miRNA) expression profiles of sporadic AD patients and found that several miRNAs potentially involved in the regulation of APP and BACE1 expression appeared to be decreased in diseased brain. We show here that miR-29a, -29b-1, and -9 can regulate BACE1 expression in vitro. The miR-29a/b-1 cluster was significantly (and AD-dementia-specific) decreased in AD patients displaying abnormally high BACE1 protein. Similar correlations between expression of this cluster and BACE1 were found during brain development and in primary neuronal cultures. Finally, we provide evidence for a potential causal relationship between miR-29a/b-1 expression and Abeta generation in a cell culture model. We propose that loss of specific miRNAs can contribute to increased BACE1 and Abeta levels in sporadic AD.

References

Nov 10, 2000·The Journal of Biological Chemistry·J W CreemersB De Strooper
Jul 12, 2002·Annals of Neurology·R M Damian HolsingerGeneviève Evin
Jul 27, 2002·Annual Review of Cell and Developmental Biology·Wim Annaert, Bart De Strooper
Sep 12, 2002·Archives of Neurology·Hiroaki FukumotoMichael C Irizarry
Dec 19, 2003·Nucleic Acids Research·Sam Griffiths-Jones
Feb 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Rena LiYong Shen
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Soeren AbelAndreas Ludwig
Sep 4, 2004·Genome Biology·Eric A MiskaH Robert Horvitz
Oct 12, 2004·Neurobiology of Disease·Sébastien S HébertBart De Strooper
Apr 23, 2005·The European Journal of Neuroscience·Lena SmirnovaF Gregory Wulczyn
Jun 10, 2005·Nature·Jun LuTodd R Golub
Jul 1, 2005·The Journal of Biological Chemistry·Diana DominguezBart De Strooper
Aug 17, 2005·PLoS Computational Biology·Dominic GrünNikolaus Rajewsky
Dec 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fiona M LairdPhilip C Wong
Jan 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Magdalena SastreMichael T Heneka
Jan 20, 2006·Nature·Gerhard M SchrattMichael E Greenberg
Jul 1, 2006·The Journal of Physiology·Mark F Mehler, John S Mattick
Aug 15, 2006·Progress in Neurobiology·Steffen RossnerStefan F Lichtenthaler
Sep 23, 2006·Science·Michael WillemChristian Haass
Oct 5, 2006·Molecular Cell·Julide BilenNancy M Bonini
Jan 6, 2007·Science·Hun-Way HwangJoshua T Mendell
Apr 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jie ZhaoRobert Vassar
Jun 8, 2007·Neuron·Giuseppina TescoRudolph E Tanzi
Jun 29, 2007·Neuro-degenerative Diseases·Daniele ZacchettiJacopo Meldolesi
Jul 4, 2007·The Journal of Experimental Medicine·Anne SchaeferPaul Greengard
Sep 1, 2007·Science·Sébastien S Hébert, Bart De Strooper
Sep 1, 2007·Science·Jongpil KimAsa Abeliovich
Sep 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Muller FabbriCarlo M Croce

❮ Previous
Next ❯

Citations

Jun 28, 2011·Cellular and Molecular Life Sciences : CMLS·Jürgen GötzXin Liu
Jul 14, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Christopher R Sibley, Matthew J A Wood
Aug 2, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Christian BarbatoCarlo Cogoni
Feb 12, 2013·Pflügers Archiv : European journal of physiology·Toni R PakNatasha N Mott
Jan 13, 2012·Modern Rheumatology·Shuji Takada, Hiroshi Asahara
Sep 17, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sowmya V Yelamanchili, Howard S Fox
Sep 19, 2009·Neuromolecular Medicine·Emmette R HutchisonMark P Mattson
Jul 2, 2011·Journal of Molecular Neuroscience : MN·Nicole SchonrockJürgen Götz
Oct 5, 2011·Molecular Neurobiology·Shan Bian, Tao Sun
Oct 12, 2012·Molecular Neurobiology·Lin TanLan Tan
Oct 24, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Chendhore S VeerappanGiovanni Coppola
Jul 12, 2013·Drugs & Aging·Genevieve Evin, Christopher Hince
Jan 24, 2012·Lancet Neurology·Evgenia Salta, Bart De Strooper
Aug 4, 2012·Cell Death and Differentiation·M-L VolvertL Nguyen
Jun 29, 2013·Cell Death & Disease·A J KoleM Deshmukh
Apr 12, 2012·Cell Research·Sherry Aw, Stephen M Cohen
May 25, 2011·Molecular Psychiatry·M D Li, A D van der Vaart
Jul 9, 2008·Nature Medicine·Peter St George-Hyslop, Christian Haass
Sep 9, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Latha Devi, Masuo Ohno
Mar 2, 2010·Nature Reviews. Drug Discovery·Adriano Aguzzi, Tracy O'Connor
Nov 19, 2011·Nature Reviews. Genetics·Manel Esteller
Nov 12, 2009·Nature Reviews. Neuroscience·Stephen M EackerValina L Dawson
Jul 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Eunsung JunnM Maral Mouradian
Feb 7, 2009·The Journal of Biological Chemistry·Luca GilibertoMassimo Tabaton
Jan 18, 2011·Antioxidants & Redox Signaling·Ying XiongDanyelle M Townsend
Oct 1, 2009·Bioinformatics·Panagiotis AlexiouArtemis G Hatzigeorgiou
Sep 13, 2011·Brain : a Journal of Neurology·Farshid NoorbakhshChristopher Power
Feb 17, 2010·Database : the Journal of Biological Databases and Curation·A LaganàA Ferro
Apr 16, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Olivier C MaesEugenia Wang
Mar 20, 2009·Human Molecular Genetics·Marc S Weinberg, Matthew J A Wood
Aug 3, 2011·Human Molecular Genetics·Pascal Y SmithSébastien S Hébert
Apr 16, 2013·Human Molecular Genetics·Hon-Kit Andus WongAnna M Krichevsky
Feb 1, 2011·Journal of Molecular Cell Biology·Liqin Du, Alexander Pertsemlidis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.