Loss of Mitochondrial Tumor Suppressor Genes Expression Is Associated with Unfavorable Clinical Outcome in Head and Neck Squamous Cell Carcinoma: Data from Retrospective Study

PloS One
Ishrat Mahjabeen, Mahmood Akhtar Kayani

Abstract

Mitochondrial genes play important roles in cellular energy metabolism, free radical generation, and apoptosis. Dysregulation of these genes have long been suspected to contribute to the generation of reactive oxygen species (ROS), increased proliferation and progression of cancer. A family of orthologues of yeast silent information regulator 3 (SIRT3), 4 (SIRT4) and mitochondrial tumor suppressor 1 (MTUS1) are important mitochondrial tumor suppressor genes which play an important role in the progression of multiple cancers. However, their role in the development of oxidative stress, enhanced proliferation and progression of head and neck squamous cell carcinoma (HNSCC) has not yet been studied. In this study we aimed to test the association between reduced mitochondrial tumor suppressor genes' activities and enhancement in tissue oxidative stress and cell proliferation in HNSCC cases. The expression of mitochondrial tumor suppressor genes (SIRT3, SIRT4 and MTUS1), mitochondrial DNA repair gene (OGG1-2a) and a proliferation marker (Ki-67) was studied in a study cohort of 120 HNSCC patients and controls with reverse transcriptase polymerase chain reaction (RT-PCR) and real-time PCR (qPCR) in order to determine the potential prog...Continue Reading

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Citations

Jan 18, 2018·Antioxidants & Redox Signaling·Tanveer SharifShashi Gujar
Nov 18, 2017·Experimental & Molecular Medicine·Hyun-Chul KimHo Jeong Kwon
Jan 18, 2018·Archives of Environmental & Occupational Health·Zertashia AkramIshrat Mahjabeen
Mar 5, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Renea P JablonskiDavid W Kamp
Sep 4, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marcin BulerJukka Hakkola
Nov 15, 2016·International Journal of Oncology·Yanlu XiongLintao Jia
May 7, 2020·Bioscience Reports·Anum Zehra NaqviMahmood Akhtar Kayani
Apr 25, 2020·Experimental Biology and Medicine·Sheng-Fan WangHsin-Chen Lee
Jul 18, 2020·Cancer Biomarkers : Section a of Disease Markers·Changming WangChuize Kong
May 20, 2016·Cancer Research·Jasmine George, Nihal Ahmad
Feb 16, 2021·Frontiers in Oncology·Yibing BaiYanqiao Zhang
Apr 19, 2021·The FEBS Journal·Amit JaiswalGabriele Saretzki

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Methods Mentioned

BETA
electrophoresis
PCR
acetylation

Software Mentioned

Quantity One
SPSS
GraphPad Prism5

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