Loss of nocturnal blood pressure fall after liver transplantation during immunosuppressive therapy

American Journal of Hypertension
Sandra J TalerR A Krom

Abstract

Hypertension, which develops after organ transplantation during immunosuppression with cyclosporine (CSA), is often associated with a loss of nocturnal decrease in blood pressure. Few data correlate circadian blood pressure patterns before transplant with those observed at fixed time points after transplant, or address the role of alternate immunosuppressive agents such as FK506. FK506 is unrelated structurally to CSA and less often leads to hypertension early after transplant. The present study compared nocturnal blood pressure patterns in patients with end-stage liver disease (ESLD) before transplant to those of transplant recipients receiving either FK506 (0.15 mg/kg/day) plus prednisone or CSA (2 to 3 mg/kg/day) plus prednisone and azathioprine after orthotopic liver transplantation. Overnight ambulatory blood pressure profiles were studied in 13 pretransplant ESLD patients and in 34 patients (FK506: n = 13; CSA: n = 21) treated with different steroid doses (24 +/- 11 mg/day FK506; 34 +/- 3 mg/day CSA), according to protocol, 4 weeks (range, 2 to 7 weeks) after liver transplant. Mean blood pressure and heart rate values from awake and nocturnal 5-h time blocks were compared to 13 normotensive control subjects. Patients with...Continue Reading

Citations

Sep 16, 2004·Pediatric Transplantation·Marianne Soergel
Jul 31, 2007·Advanced Drug Delivery Reviews·Ramón C HermidaFrancesco Portaluppi
Jul 29, 2004·Transplantation·Stephen C TextorMark Stegall
Apr 6, 2007·Journal of the American Society of Nephrology : JASN·Hani M WadeiStephen C Textor
Sep 25, 2002·Canadian Journal of Physiology and Pharmacology·Mahmoud M El-MasFouad M Sharabi
Apr 29, 2000·Current Opinion in Urology·A R Rosenkranz, G Mayer
Aug 15, 1996·Annals of the New York Academy of Sciences·M H Smolensky, F Portaluppi
Feb 11, 2012·Pediatric Transplantation·Umut Selda BayrakciMehmet Haberal
Sep 1, 1996·Journal of Transplant Coordination : Official Publication of the North American Transplant Coordinators Organization (NATCO)·L SchwartzS Textor
Jan 10, 2012·Clinical Transplantation·G V Ramesh Prasad
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Stephen C TextorMark Stegall
Jun 11, 1999·Journal of the American Society of Nephrology : JASN·J M SorofR J Portman
Jun 15, 2010·Transplantation Reviews·Hani M Wadei, Stephen C Textor

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