Loss of nonclassical MHC molecules MIC-A/B expression during progression of uveal melanoma

British Journal of Cancer
Claudia S VetterJürgen C Becker

Abstract

Uveal melanoma differs from cutaneous melanoma with respect to aetiology, metastatic behaviour and immune biology. The notion that loss of classical MHC class I molecules in uveal melanoma lesions is associated with an improved prognosis suggests that NK cells act as the predominant cells responsible for immune surveillance of this tumour. Consequently, immune escape mechanisms of uveal melanoma should impair the innate immunity. To this end, expression of the ligand for the NK receptor NKG2D, that is, MIC-A/B was expressed by 50% of primary tumours, but none of the metastatic lesions. MIC+ tumours were characterised by a NKG2D+ infiltrate, which was absent in MIC- lesions subsequent to chemoimmune therapy. Strikingly, MIC-A/B expression in metastatic lesions was observed subsequent to chemotherapy with fotemustine in one case. In summary, MIC/NKG2D interactions seem to be involved in the immune surveillance of primary uveal melanomas, whereas for metastatic tumours this ligand/receptor system seems not to be relevant, thus, suggesting an immune selection of MIC negative tumour cells.

References

May 1, 1992·Survey of Ophthalmology·D M AlbertJ K Willson
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C Hunt, R I Morimoto
Oct 1, 1993·Immunology Today·F GarridoP L Stern
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·V GrohT Spies
Mar 20, 1998·The British Journal of Ophthalmology·D J BlomM J Jager
Dec 1, 1998·Genes & Development·L ChinR A DePinho
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·V GrohT Spies
Jan 11, 2000·Developments in Ophthalmology·B R Ksander, P W Chen
Feb 5, 2000·Human Immunology·I AlgarraF Garrido
Jun 22, 2000·International Journal of Cancer. Journal International Du Cancer·N C NausA Klein
Jun 29, 2001·Trends in Immunology·H A Stephens
Mar 29, 2002·The Journal of Investigative Dermatology·Claudia S VetterJürgen C Becker
Jun 1, 2002·Human Immunology·Martine J JagerRolf Kiessling
Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Aug 15, 2002·Human Immunology·Robert W M CollinsRobert W Vaughan
Dec 10, 2002·Trends in Molecular Medicine·Scott C Edmunds, David P Kelsell
Dec 13, 2002·Vaccine·Michael CampoliSoldano Ferrone
Jan 28, 2003·Trends in Immunology·Barbara SeligerSoldano Ferrone
Jun 26, 2003·Investigative Ophthalmology & Visual Science·Yoram CohenDavid Sidransky
Jul 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Veronika GrohThomas Spies
Dec 17, 2003·British Journal of Cancer·L Lo MuzioD C Altieri

❮ Previous
Next ❯

Citations

Aug 13, 2011·Cancer Immunology, Immunotherapy : CII·Riccardo DanielliMichele Maio
Sep 16, 2008·Protein Engineering, Design & Selection : PEDS·Claire GermainBruno Robert
Jan 19, 2010·The Journal of Biological Chemistry·Lola Fernández-MessinaMar Valés-Gómez
Jan 19, 2016·Frontiers in Immunology·Raquel TarazonaRafael Solana
Apr 9, 2014·Frontiers in Immunology·Leticia Huergo-ZapicoSegundo Gonzalez
Dec 18, 2008·International Journal of Cancer. Journal International Du Cancer·Nicole SchwinnAnnette Paschen
Aug 4, 2007·Nature Reviews. Immunology·Robert A Eagle, John Trowsdale
Dec 15, 2012·Eye·I H G Bronkhorst, M J Jager
May 16, 2009·Expert Opinion on Therapeutic Patents·Mario Milco D'EliosAmedeo Amedei
Aug 13, 2014·Pigment Cell & Melanoma Research·Jason J LukeRichard D Carvajal
Jun 15, 2017·Future Oncology·Benjamin DemoulinSophie Agaugue
Feb 6, 2020·International Journal of Molecular Sciences·Anja WesselyMarkus Vincent Heppt
Aug 18, 2010·Immunology and Cell Biology·Antonio E SerranoMaría-Carmen Molina
Jan 22, 2014·Immunology and Cell Biology·Nina Le Bert, Stephan Gasser
Aug 28, 2016·Clinical & Experimental Metastasis·Powrnima JoshiPierre L Triozzi
Nov 22, 2019·Frontiers in Oncology·Maria Sofia BasileMichele Reibaldi
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·James E ButlerCharles T Lutz
Jul 22, 2019·Journal of Experimental & Clinical Cancer Research : CR·Jian WuTian-Yang Dai
Jun 12, 2010·Immunological Reviews·Marine Champsaur, Lewis L Lanier
Feb 24, 2017·Cancer Metastasis Reviews·Adriana AmaroUlrich Pfeffer
Jun 1, 2016·Melanoma Management·Dae Won KimSapna P Patel
Feb 6, 2017·Frontiers in Immunology·Gerald MoncayoChristopher A O'Callaghan
Nov 17, 2020·Frontiers in Oncology·Huan LuoJing Cao
Aug 13, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Annette PaschenSelma Ugurel
Jun 25, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Loretta GammaitoniDario Sangiolo
Oct 26, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Claire GermainBruno Robert
Dec 16, 2020·Cancers·Asad Javed, Mohammed Milhem
Mar 12, 2018·Current Opinion in Immunology·Payal Dhar, Jennifer D Wu
May 1, 2021·Cancers·Mariarosaria MarsegliaMichela Croce

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.