Loss of notch activity in the developing central nervous system leads to increased cell death

Developmental Neuroscience
Heather A MasonGord Fishell

Abstract

Many cells in the mammalian brain undergo apoptosis as a normal and critical part of development but the signals that regulate the survival and death of neural progenitor cells and the neurons they produce are not well understood. The Notch signaling pathway is involved in multiple decision points during development and has been proposed to regulate the survival and apoptosis of neural progenitor cells in the developing brain; however, previous experiments have not resolved whether Notch activity is pro- or anti-apoptotic. To elucidate the function of Notch signaling in the survival and death of cells in the nervous system, we have produced single and compound Notch conditional mutants in which Notch1 and Notch3 are removed at different times during brain development and in different populations of cells. We show here that a large number of neural progenitor cells, as well as differentiating neurons, undergo apoptosis in the absence of Notch1 and Notch3, suggesting that Notch activity promotes the survival of both progenitors and newly differentiating cells in the developing nervous system. Finally, we show that postmitotic neurons do not require Notch activity indefinitely to regulate their survival since elevated levels of ce...Continue Reading

References

Jan 1, 1991·Annual Review of Neuroscience·R W Oppenheim
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B Sauer, N Henderson
Jan 9, 1999·Immunity·M L DeftosM J Bevan
Apr 30, 1999·Science·S Artavanis-TsakonasR J Lake
Aug 28, 1999·Neuroscience·O BerezovskaB T Hyman
Sep 7, 1999·Nature·A ApelqvistH Edlund
Oct 21, 1999·Journal of Cellular Physiology·L Miele, B Osborne
Dec 22, 1999·Nature Neuroscience·L RedmondA Ghosh
Jun 17, 2000·Trends in Neurosciences·C Y KuanP Rakic
Sep 1, 2000·The Journal of Biological Chemistry·T MorimuraD Kitamura
Sep 28, 2000·Trends in Neurosciences·E J de la Rosa, F de Pablo
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H T Tan-PertelJ C Gasson
Dec 6, 2000·Genesis : the Journal of Genetics and Development·A NovakC G Lobe
Dec 6, 2001·Cerebral Cortex·Thorsten StühmerJohn L R Rubenstein
Feb 28, 2002·Current Opinion in Neurobiology·Carol Schuurmans, François Guillemot
Feb 28, 2002·Current Opinion in Neurobiology·Nicholas J Justice, Yuh Nung Jan
Nov 5, 2003·Genesis : the Journal of Genetics and Development·Luke T KrebsThomas Gridley
Jan 3, 2004·Nature Neuroscience·Stephen C NoctorArnold R Kriegstein
Oct 29, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Keejung YoonNicholas Gaiano
May 10, 2005·Genes & Development·Todd E AnthonyNathaniel Heintz
Aug 27, 2005·Development·Heather A MasonGord Fishell

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Citations

Apr 25, 2007·Apoptosis : an International Journal on Programmed Cell Death·Klas BlomgrenLaurent Groc
Apr 21, 2011·Nature Reviews. Neuroscience·Jessica L AblesPasko Rakic
Sep 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yun LiLuis F Parada
Mar 21, 2007·Molecular and Cellular Biology·Motoshi NagaoMasato Nakafuku
Apr 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Leslie CrewsEliezer Masliah
Feb 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kanika GhaiAndy J Fischer
Aug 2, 2011·Annual Review of Cell and Developmental Biology·Maria K Lehtinen, Christopher A Walsh
Sep 21, 2010·Brain Research Bulletin·Xi-Tao YangDong-Fu Feng
Jul 11, 2007·Journal of Neuropathology and Experimental Neurology·Francoise GrayHugues Chabriat
Mar 8, 2016·Cerebral Cortex·Sara Anna BoniniMaurizio Memo
Nov 15, 2008·Progress in Neurobiology·Shu WenJia Liu
Mar 29, 2008·Molecular and Cellular Neurosciences·Luisa PintoMagdalena Götz
Dec 20, 2008·Journal of Neurochemistry·Justin D LathiaAiwu Cheng
Nov 3, 2011·Journal of Applied Toxicology : JAT·Jyotshna KanungoMerle G Paule
Apr 15, 2014·Hematology·Shirin AzizidoostNajmaldin Saki
Feb 11, 2015·Seminars in Cell & Developmental Biology·Richa Arya, Kristin White
Mar 23, 2017·Scientific Reports·Marine H LaporteRémy Sadoul
Mar 2, 2006·Developmental Neuroscience·Maria I GivogriErnesto R Bongarzone
Jul 16, 2011·Development and Psychopathology·Clancy BlairUNKNOWN Family Life Project Key Investigators
Nov 2, 2019·Investigative Ophthalmology & Visual Science·Thomas FlemingCarlos G Martínez-Moreno
Dec 18, 2020·The Journal of Cell Biology·Masataka KuniiAkihiro Harada
Feb 9, 2017·Neuroreport·Ji-Hye YoonHee-Sae Park
Dec 15, 2020·Neuroscience Research·Shun MaseFumio Matsuzaki

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