Loss of nuclear factor-kappaB is tumor promoting but does not substitute for loss of p53

Cancer Research
K M RyanKaren H Vousden

Abstract

Inactivation of apoptotic pathways is a common event in cancer. Two transcription factors that regulate apoptosis during tumorigenesis are p53 and nuclear factor (NF)-kappaB. Although NF-kappaB is generally considered a suppressor of cell death, we showed previously that NF-kappaB can contribute to p53-induced death. Here, we show that loss of p65, a critical subunit of NF-kappaB, can cause resistance to different agents that signal death through p53. Loss of p65 also enhances tumorigenesis induced by E1a and Ras. Unlike loss of p53, however, loss of p65 does not cause anchorage-independent growth or enable tumor development following expression of a single oncogene. These findings reaffirm the role of NF-kappaB in p53-induced death but show that its loss does not substitute for loss of p53 in tumor development. Moreover, this indicates that, although perhaps central to p53 function, loss of the ability to induce programmed cell death does not completely inactivate p53's tumor-suppressive effects.

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Citations

Feb 20, 2008·Angiogenesis·Sebastien P Tabruyn, Arjan W Griffioen
Sep 1, 2005·Apoptosis : an International Journal on Programmed Cell Death·M TavassoliJ Gäken
Aug 11, 2006·Journal of Mammary Gland Biology and Neoplasia·Michael C HaffnerWolfgang Doppler
Feb 17, 2007·Cell Death and Differentiation·D CrightonK M Ryan
Mar 18, 2009·Molecular and Cellular Biology·Tamara CopettiClaudio Schneider
Nov 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Katerina V GurovaAndrei V Gudkov
Jan 18, 2006·Cell Death and Differentiation·N D Perkins, T D Gilmore
May 2, 2015·Cell Death and Differentiation·M MrschtikK M Ryan
Nov 16, 2011·Autophagy·Li Yen MahKevin M Ryan
Oct 22, 2008·Journal of Experimental & Clinical Cancer Research : CR·Ibrahim MeteogluSabri Barutca
May 26, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·De-Chen LinMing-Rong Wang
Oct 19, 2010·Biochimica Et Biophysica Acta·Günter Schneider, Oliver H Krämer

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