Abstract
5-Hydroxymethylcytosine (5hmC) is lost in multiple human cancers, including colorectal cancer (CRC). Decreased ten-eleven translocation 1 (TET1) messenger RNA (mRNA), but not other two TET family members, has been observed in the colorectal cancer and is crucial for colorectal cancer initiation. Here, we show that nuclear localization of TET2 was lost in a significant portion of CRC tissues, in association with metastasis. In CRC cells, nuclear expression of TET2 were absent but not TET3. Nuclear export inhibitor can increase the 5hmC level in CRC cells, probably through regulating TET2. Our results indicate a new mechanism of TET2 dysregulation in colorectal cancer.
References
Oct 15, 2008·Annual Review of Pharmacology and Toxicology·Moshe Szyf
Jan 17, 2009·Cancer Research·Sarah C MutkaSumati Murli
Nov 9, 2010·Nature·Myunggon KoAnjana Rao
Nov 5, 2011·Cancer Research·Seung-Gi JinGerd P Pfeifer
Feb 11, 2012·Cancer Science·Yotaro KudoKazuhiko Koike
Mar 7, 2012·Oncogene·H YangY Xiong
Jun 13, 2012·The American Journal of Pathology·Tim MüllerAndreas Waha
Sep 5, 2012·Nature Reviews. Genetics·Holger Heyn, Manel Esteller
Dec 18, 2013·Nature·Bruno Di StefanoThomas Graf
Nov 5, 2014·Oncogene·F NeriS Oliviero
Jan 6, 2015·Journal of Cancer Research and Clinical Oncology·Agnieszka Anna Rawłuszko-WieczorekPaweł Piotr Jagodziński
Apr 9, 2015·Genome Biology·Santiago Uribe-LewisAdele Murrell
Sep 15, 2015·Clinical Epigenetics·Sahar Olsadat SajadianAndreas K Nussler
Citations
May 4, 2016·Human Reproduction·Kai NiUndraga Schagdarsurengin
Jan 24, 2018·Carcinogenesis·Lili ChenXiuli Bi
Sep 27, 2019·Familial Cancer·Anne M L JansenAjay Goel
Jun 15, 2018·Oncotarget·María G GarcíaMario F Fraga
Aug 25, 2016·Oncotarget·Hao LianWei-Lin Jin
Feb 11, 2020·Human Molecular Genetics·Ting-Ting WuYun-Cheng Wu
Dec 25, 2019·Signal Transduction and Targeted Therapy·Yuan ChengXiawei Wei
Sep 11, 2020·BMC Bioinformatics·Zhen-Zhen XueYing-Ying Xu
May 27, 2016·Scientific Reports·Lili LiQian Tao
Mar 1, 2017·Cold Spring Harbor Perspectives in Medicine·Robert L Bowman, Ross L Levine
Aug 11, 2020·Frontiers in Endocrinology·Yiwen XuHuijuan Zhu
Sep 19, 2020·Biomarker Research·Chen XueLanjuan Li
Sep 29, 2020·PeerJ·Jingni WuXiaoling Fang
Jul 27, 2018·BMC Cancer·Elham BarazeghiGunnar Westin
Jul 11, 2018·Cell Death & Disease·Sandra AtlanteCarlo Gaetano
Jan 21, 2021·Trends in Cancer·Julie K BrayAnirban Maitra
Feb 6, 2020·Cell Reports·Yetao XuYingqun Huang
Dec 17, 2020·Signal Transduction and Targeted Therapy·Yuan ChengXiawei Wei
Mar 12, 2021·Applied Biochemistry and Biotechnology·Ashikh SeethySubhradip Karmakar
Apr 4, 2021·Cancers·Manuela GiansantiGrazia Graziani
Jan 20, 2021·Cellular and Molecular Life Sciences : CMLS·Siyuan LuanYong Yuan
May 4, 2021·Frontiers in Neurology·Xuan LiYun-Cheng Wu
May 22, 2021·Aging·Danlei ChenSiying Wang
Nov 6, 2018·Biochemistry·Jamie E DeNizioRahul M Kohli