Loss of nuclear localization of TET2 in colorectal cancer.

Clinical Epigenetics
Yuji HuangChen-Ying Liu

Abstract

5-Hydroxymethylcytosine (5hmC) is lost in multiple human cancers, including colorectal cancer (CRC). Decreased ten-eleven translocation 1 (TET1) messenger RNA (mRNA), but not other two TET family members, has been observed in the colorectal cancer and is crucial for colorectal cancer initiation. Here, we show that nuclear localization of TET2 was lost in a significant portion of CRC tissues, in association with metastasis. In CRC cells, nuclear expression of TET2 were absent but not TET3. Nuclear export inhibitor can increase the 5hmC level in CRC cells, probably through regulating TET2. Our results indicate a new mechanism of TET2 dysregulation in colorectal cancer.

References

Oct 15, 2008·Annual Review of Pharmacology and Toxicology·Moshe Szyf
Jan 17, 2009·Cancer Research·Sarah C MutkaSumati Murli
Jun 13, 2012·The American Journal of Pathology·Tim MüllerAndreas Waha
Sep 5, 2012·Nature Reviews. Genetics·Holger Heyn, Manel Esteller
Jan 6, 2015·Journal of Cancer Research and Clinical Oncology·Agnieszka Anna Rawłuszko-WieczorekPaweł Piotr Jagodziński
Apr 9, 2015·Genome Biology·Santiago Uribe-LewisAdele Murrell

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Citations

Sep 27, 2019·Familial Cancer·Anne M L JansenAjay Goel
Jun 15, 2018·Oncotarget·María G GarcíaMario F Fraga
Dec 25, 2019·Signal Transduction and Targeted Therapy·Yuan ChengXiawei Wei
Mar 1, 2017·Cold Spring Harbor Perspectives in Medicine·Robert L Bowman, Ross L Levine
Jul 11, 2018·Cell Death & Disease·Sandra AtlanteCarlo Gaetano
Jan 21, 2021·Trends in Cancer·Julie K BrayAnirban Maitra
Feb 6, 2020·Cell Reports·Yetao XuYingqun Huang
Dec 17, 2020·Signal Transduction and Targeted Therapy·Yuan ChengXiawei Wei
Mar 12, 2021·Applied Biochemistry and Biotechnology·Ashikh SeethySubhradip Karmakar
Jan 20, 2021·Cellular and Molecular Life Sciences : CMLS·Siyuan LuanYong Yuan

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Methods Mentioned

BETA
nuclear translocation

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