Loss of occludin and functional tight junctions, but not ZO-1, during neural tube closure--remodeling of the neuroepithelium prior to neurogenesis

Developmental Biology
E Aaku-SarasteWieland B Huttner

Abstract

Neuroepithelial cells can generate nonepithelial cells, the neurons. Here we have investigated, for chick and mouse embryos, the epithelial character of neuroepithelial cells in the context of neurogenesis by examining the presence of molecular components of tight junctions during the transition from the neural plate to the neural tube. Immunoreactivity for occludin, a transmembrane protein specific to tight junctions, was detected at the apical end of the lateral membrane of neuroepithelial cells throughout the chick neural plate. During neural tube closure, occludin disappeared from all neuroepithelial cells. Correspondingly, the addition of horseradish peroxidase to the apical side of the neuroepithelium by injection into the amniotic cavity of mouse embryos revealed the presence of functional tight junctions in the neural plate (Embryonic Day 8), but not the neural tube (Embryonic Day 9). In contrast to occludin, expression of ZO-1, a peripheral membrane protein of tight junctions, increased from the neural plate to the neural tube stage, also being confined to the apical end of the lateral neuroepithelial cell membrane. This localization coincided with that of N-cadherin, whose expression increased concomitantly with the d...Continue Reading

Citations

Aug 31, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Naoyuki ManabeShigeo Ohno
Feb 2, 2008·Histochemistry and Cell Biology·Jantina A ManningSharad Kumar
Sep 12, 2007·Cell and Tissue Research·Paolo MalatestaFilippo Calzolari
Sep 23, 2003·Developmental Biology·Artem JarovClaire Fournier-Thibault
Mar 20, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M Hollyday
Feb 1, 1997·Current Opinion in Neurobiology·W B Huttner, M Brand
Apr 12, 2013·Nature Communications·Bridget E LaMonicaArnold R Kriegstein
Nov 30, 2005·Nature Reviews. Molecular Cell Biology·Magdalena Götz, Wieland B Huttner
Jun 5, 2008·Nature Reviews. Molecular Cell Biology·Tatjana Sauka-Spengler, Marianne Bronner-Fraser
Jan 18, 2007·Nature Reviews. Neuroscience·Joshua J Buchman, Li-Huei Tsai
Nov 26, 2011·Stem Cells and Development·Sandra StelzerJens C Schwamborn
Jan 17, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sei Kuriyama, Roberto Mayor
Dec 3, 2008·Development, Growth & Differentiation·Yukiko Nakaya, Guojun Sheng
Jan 9, 2009·Development, Growth & Differentiation·Jean-Loup DubandClaire Fournier-Thibault
Apr 22, 2009·Development, Growth & Differentiation·Yoichi Kosodo, Wieland B Huttner
Apr 25, 2012·Development, Growth & Differentiation·Elise Peyre, Xavier Morin
Apr 29, 1998·Annual Review of Physiology·L L Mitic, J M Anderson
Apr 12, 2008·Development·Karpagam SrinivasanSusan K McConnell
Sep 18, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiaojun YangXiangyun Wei
Jun 19, 2013·Cellular and Molecular Life Sciences : CMLS·Sandra Gómez-LópezClaudia Petritsch
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·A WeigmannW B Huttner
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Margaret E McLaughlinTyler Jacks
Jul 9, 2014·Annual Review of Cell and Developmental Biology·Elena TavernaWieland B Huttner
Feb 18, 2016·Scientific Reports·Elena TavernaWieland B Huttner
Jan 24, 2016·Neuroscience Research·Jacobus J DudokJan Wijnholds
Dec 19, 2012·Trends in Neurosciences·Jakub K Famulski, David J Solecki
May 23, 2003·Glia·Arnold R Kriegstein, Magdalena Götz
Aug 16, 2012·Archives of Biochemistry and Biophysics·Masayuki Yamashita
Aug 24, 2013·Journal of Neuropathology and Experimental Neurology·Cristian OliverLuis Federico Bátiz
May 12, 2012·Seminars in Cancer Biology·Pablo H Strobl-Mazzulla, Marianne E Bronner
Mar 27, 2015·Glia·Camino De Juan Romero, Víctor Borrell
Apr 22, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Dirk JunghansRolf Kemler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Naoyuki ManabeShigeo Ohno
Nature Reviews. Molecular Cell Biology
Magdalena Götz, Wieland B Huttner
Molecular and Cellular Neurosciences
A ChennS K McConnell
© 2021 Meta ULC. All rights reserved