Loss of orphan nuclear receptor GCNF function disrupts forebrain development and the establishment of the isthmic organizer

Developmental Biology
Arthur C-K ChungAustin J Cooney

Abstract

The isthmic organizer, which is located at the midbrain-hindbrain boundary, is important for midbrain development. The mechanism by which the development of the organizer is initiated and maintained is not well understood. Inactivation of the gene encoding the orphan nuclear receptor, GCNF, diminishes the expression of secreted signaling molecules, Fgf8 and Wnt1, the paired box genes Pax2/5, En1/2, and homeodomain transcription factor Gbx2; all of which are essential for isthmic organizer function. In addition, full neuronal differentiation is not observed in the midbrain region of GCNF-/- embryos. Increased cell death may contribute to the loss of midbrain structure in GCNF-/- embryos. These results indicate that GCNF is required for establishment of the isthmic organizer, thereby regulating the midbrain development.

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Citations

Jan 24, 2009·Biology of Reproduction·Zi-Jian LanAustin J Cooney
Aug 22, 2009·Experimental & Molecular Medicine·Yangsik Jeong, David J Mangelsdorf
Sep 14, 2013·Seminars in Cell & Developmental Biology·Qin Wang, Austin J Cooney
Nov 8, 2015·The International Journal of Biochemistry & Cell Biology·Yinfang WangPeng Zhang
Aug 21, 2014·PloS One·Davood SabourAustin J Cooney
Jan 16, 2018·Nuclear Receptor Research·Shari BodofskyBruce Wightman
Jun 24, 2017·Cellular and Molecular Life Sciences : CMLS·Dimitrios GkikasPanagiotis K Politis
Jul 19, 2019·Cell Communication and Signaling : CCS·Yinfang WangPeng Zhang

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