Loss of phosphatase and tensin homologue deleted on chromosome 10 and phosphorylation of mammalian target of rapamycin are associated with progesterone refractory endometrial hyperplasia

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
M R MilamK H Lu

Abstract

The objective of our study was to evaluate the phosphatase and tensin homologue deleted on chromosome 10 (PTEN), p27, and mammalian target of rapamycin (mTOR) expressions in women with progesterone-responsive and refractory endometrial hyperplasia (EH) samples and to determine if these markers could be associated with response or used as potential targets for treatment. Thirty-eight matched pre- and posttreatment pairs of paraffin-embedded endometrial biopsies were obtained from patients with EH. Immunohistochemical analysis for PTEN, p27, and phospho-mTOR were performed on all samples. Median age at diagnosis was 49 years (20-79 years). Median treatment interval was 3 months (1-12 months). Sixteen patients (42.1%) had complete resolution of their hyperplasia (responders), and 22 (57.9%) had persistent hyperplasia (nonresponders) after treatment with progesterone. In the pretreatment samples, no markers were found to predict nonresponders. In posttreatment samples, loss of PTEN expression with phospho-mTOR expression was observed in more nonresponders than responders (40.9% vs 6.3%; P= 0.03). Phospho-mTOR overexpression was found in 63.6% of nonresponders. We found that persistent hyperplasia refractory to progesterone therapy ...Continue Reading

References

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Mar 10, 2007·American Journal of Obstetrics and Gynecology·Michael R MilamKaren H Lu

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Citations

Sep 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sanaz MemarzadehOwen N Witte
Jul 9, 2010·Obstetrics and Gynecology International·Ying Zhang, Jian Wang
Dec 6, 2014·Journal of Animal Science and Biotechnology·Qinglei Li
Oct 12, 2010·American Journal of Obstetrics and Gynecology·Ioannis D GallosJanesh K Gupta
Apr 18, 2008·Expert Review of Neurotherapeutics·Daphne Haas-Kogan, David Stokoe
Dec 7, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sharmilee Bansal KoretsRobert J Schneider
Oct 14, 2010·Disease Models & Mechanisms·David F Restuccia, Brian A Hemmings

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