Loss of PKC lambda/iota impairs Th2 establishment and allergic airway inflammation in vivo.

Proceedings of the National Academy of Sciences of the United States of America
Jun-Qi YangJ Moscat

Abstract

The differentiation of T cells along different lineages is central to the control of immunity. Here we have used a conditional gene knockout system to delete PKC lambda/iota selectively in activated T cells. With this system we have demonstrated that PKC lambda/iota is necessary for T-helper cell (Th2) cytokine production and optimal T-cell proliferation and allergic airway inflammation in vivo. Our data demonstrate that the activation of the transcription factors nuclear factor of activated T cells and NF-kappaB is impaired in PKC lambda/iota-deficient activated T cells. In addition, we present genetic knockout evidence in ex vivo experiments with primary T cells that PKC lambda/iota is critical for the control of cell polarity during T-cell activation. Therefore PKC lambda/iota emerges as a critical regulator of Th 2 activation.

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Citations

Jan 23, 2010·Nature Reviews. Molecular Cell Biology·Carine RossePeter J Parker
Jun 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Amitava SenguptaJose A Cancelas
Sep 24, 2015·Immunology and Cell Biology·Kelly M RamsbottomJane Oliaro
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Mar 23, 2012·Immunological Reviews·Maria T Diaz-Meco, Jorge Moscat
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Sep 3, 2019·Cancer Cell·Miguel Reina-CamposJorge Moscat
Oct 24, 2020·The Journal of Investigative Dermatology·Zhiping WangYuangang Liu
Dec 23, 2009·Current Opinion in Allergy and Clinical Immunology

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