Loss of plasmacytoid dendritic cell function coincides with lymphopenia and viremia during foot-and-mouth disease virus infection

Viral Immunology
Charles NfonWilliam T Golde

Abstract

Foot-and-mouth disease virus (FMDV) causes an acute, highly contagious disease of livestock. Though FMDV is very sensitive to interferon-alpha (IFN-alpha), IFN-beta, and IFN-gamma, the virus has evolved mechanisms to evade such innate responses. For instance, during acute infection, FMDV suppresses IFN-alpha production by skin and myeloid dendritic cells (DCs). We have previously reported that FMDV infection induces a transient lymphopenia and interruption of T-lymphocyte responses to mitogenic stimuli. To further understand the immunopathogenesis of FMD, we have now analyzed the serum IFN-alpha response in relation to lymphopenia, and the number and function of plasmacytoid DCs (pDCs) following infection of pigs with multiple serotypes of FMDV. Serum IFN-alpha peaked 2-3 d post-infection (PI), regardless of FMDV serotype. Lymphopenia coincided with peak viremia and the serum IFN-alpha response. Circulating pDC numbers and in-vitro pDC IFN-alpha secretion transiently declined by 48 h following infection. Infection of lymphocytes or pDCs was never detected regardless of the FMDV serotype inoculated or the age of the animal infected. These data indicate that, like other DC subsets, there is suppression of interferon production by...Continue Reading

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Citations

Apr 20, 2011·Transboundary and Emerging Diseases·W T GoldeB Charleston
Dec 24, 2010·Clinical and Vaccine Immunology : CVI·Jared R PatchWilliam T Golde
Oct 22, 2011·Veterinary Research·Miriam A WindsorBryan Charleston
Apr 12, 2013·PloS One·Nils Lannes, Artur Summerfield
Aug 26, 2014·Comparative Immunology, Microbiology and Infectious Diseases·Jared R PatchWilliam T Golde
Aug 21, 2015·The Journal of Veterinary Medical Science·Oguzhan AvciIrmak Dik
Apr 5, 2011·Veterinary Immunology and Immunopathology·Artur Summerfield
Jun 1, 2016·Frontiers in Veterinary Science·Carolina StenfeldtJonathan Arzt
Sep 17, 2016·Transboundary and Emerging Diseases·C SenthilkumaranC Nfon
Mar 9, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Felix N TokaWilliam T Golde
Nov 30, 2018·Frontiers in Microbiology·Gisselle N MedinaTeresa de Los Santos
Aug 28, 2020·Frontiers in Veterinary Science·Gisselle N MedinaFayna Diaz-San Segundo
Dec 29, 2017·Reviews in Medical Virology·Muhammad AbubakarAfshan Ahmed
Mar 16, 2021·Frontiers in Immunology·Kangli LiHaixue Zheng
Jun 16, 2021·Microbial Pathogenesis·Thalita Evani Silva de OliveiraSelwyn Arlington Headley

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Methods Mentioned

BETA
blood collection
PCR
flow cytometry
FACS
ELISA

Software Mentioned

GraphPad
GraphPad Prism

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