Loss of progesterone receptor-mediated actions induce preterm cellular and structural remodeling of the cervix and premature birth

PloS One
Steven M YellonMichael A Kirby

Abstract

A decline in serum progesterone or antagonism of progesterone receptor function results in preterm labor and birth. Whether characteristics of premature remodeling of the cervix after antiprogestins or ovariectomy are similar to that at term was the focus of the present study. Groups of pregnant rats were treated with vehicle, a progesterone receptor antagonist (onapristone or mifepristone), or ovariectomized on day 17 postbreeding. As expected, controls given vehicle delivered at term while rats delivered preterm after progesterone receptor antagonist treatment or ovariectomy. Similar to the cervix before term, the preterm cervix of progesterone receptor antagonist-treated rats was characterized by reduced cell nuclei density, decreased collagen content and structure, as well as a greater presence of macrophages per unit area. Thus, loss of nuclear progesterone receptor-mediated actions promoted structural remodeling of the cervix, increased census of resident macrophages, and preterm birth much like that found in the cervix at term. In contrast to the progesterone receptor antagonist-induced advance in characteristics associated with remodeling, ovariectomy-induced loss of systemic progesterone did not affect hypertrophy, ext...Continue Reading

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Citations

Oct 10, 2015·American Journal of Obstetrics and Gynecology·Agustin Conde-Agudelo, Roberto Romero
Aug 13, 2015·American Journal of Obstetrics and Gynecology·Amy-Eunice FurcronNardhy Gomez-Lopez
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Aug 6, 2015·Reproductive Sciences·William E AckermanDouglas A Kniss
Mar 12, 2020·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Ki Hoon AhnHai Joong Kim
Nov 22, 2017·Biology of Reproduction·Shanmugasundaram NallasamyMala Mahendroo
Apr 16, 2019·Frontiers in Endocrinology·Nishel M ShahMark R Johnson
Aug 17, 2020·Seminars in Immunopathology·Erna BayarDavid A MacIntyre
Feb 11, 2020·Frontiers in Immunology·Steven M Yellon
Feb 7, 2020·American Journal of Obstetrics and Gynecology·Agustin Conde-AgudeloKypros H Nicolaides

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