Loss of receptor activity for mouse erythrocytes precedes tumour promoter-induced maturation of chronic lymphocytic leukaemia cells

Cancer Letters
I J ForbesA W Murray

Abstract

The tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induced differentiation in lymphocytes from patients with chronic lymphocytic leukaemia (CLL). The differentiation was detected by the appearance of cytoplasmic immunoglobulin (CIg) and a plasmacytoid morphology, and was accompanied by the loss of the ability of the CLL cells to rosette with mouse erythrocytes (M). Loss of M rosetting occurred rapidly (within 10 min), was not prevented by cycloheximide or actinomycin D and was elicited by low concentrations of TPA (ED50 8 X 10(-10) M). Inhibition of rosette formation was induced by other phorbol diester promoters, but not non-promoting derivatives. Loss of the capacity to form M rosettes occurs before events which are evidently related to genome activation.

References

Oct 1, 1978·Australian and New Zealand Journal of Medicine·I J ForbesP A Cowled
Mar 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S GuptaF P Siegal
Jun 1, 1976·British Journal of Haematology·D CatovskyD A Galton
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·T J SlagaG L Gleason

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Citations

Sep 1, 1983·Journal of Reproductive Immunology·H ZolaP C Beverley
Sep 1, 1983·Cancer Genetics and Cytogenetics·D F Callen, J H Ford
Jul 1, 1991·Experimental Cell Research·I J ForbesC Giannakis

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