Loss of Regulatory Immune Function in Coronary Artery Disease Patients from the Indian Population

Journal of Cardiovascular Translational Research
Thiruvelselvan PonnusamyLakshmi A Mundkur

Abstract

The pathogenic roles of inflammatory T cells and monocytes subsets have not been explored in different manifestations of coronary artery disease. We studied the frequency of these cells, their response to autoantigens, regulatory cell functional assay, foam cell formation and macrophage differentiation in 181 patients (stable angina, ST-elevated myocardial infarction (STEMI), NSTEMI, and unstable angina), and 34 controls and in samples collected during recurrent cardiac events and from patients showing clinical improvement. The proportion of Th17 cells and monocytes gradually increased in patients with stable angina at one end of the spectrum followed by NSTEMI, STEMI, and unstable angina at other end. Inflammatory cells were positively and inversely associated with recurrent events and clinical improvement, respectively. Patients showed expansion of Th17 cells in response to autoantigen (HSP60) and compromised Treg function. Our results suggest that stress-induced activation of inflammatory cells expands in the absence of regulatory control in CAD patients.

References

Mar 1, 1987·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·U P SteinbrecherD Steinberg
Sep 7, 2000·Circulation·G CaligiuriG K Hansson
Feb 6, 2002·Circulation·Takako NakajimaCornelia M Weyand
Jun 1, 2002·Circulation Research·Alan Daugherty, Debra L Rateri
Jan 7, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Guilhem LarigauderieMustapha Rouis
Jan 20, 2005·The Journal of Experimental Medicine·Claire L LangrishDaniel J Cua
Feb 8, 2006·Nature Medicine·Hafid Ait-OufellaZiad Mallat
Jun 17, 2006·Nature Reviews. Immunology·Göran K Hansson, Peter Libby
Jun 22, 2006·International Journal of Cardiology·Dimitris TousoulisChristodoulos Stefanadis
Feb 10, 2007·Autoimmunity Reviews·Janette Furuzawa-CarballedaAntonio R Cabral
Feb 20, 2007·Current Opinion in Immunology·Adrian Liston, Alexander Y Rudensky
Feb 26, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Xiang ChengYu-Hua Liao
May 31, 2008·Cell·Shimon SakaguchiMasahiro Ono
Oct 1, 2008·Nature Reviews. Immunology·Christian WeberPeter Libby
Dec 4, 2008·Journal of Lipid Research·Ziad MallatAlain Tedgui
Aug 19, 2009·European Heart Journal·Kyrill S RogacevGunnar H Heine
Dec 17, 2009·Journal of Lipid Research·Jing LinDazhu Li
Sep 4, 2010·Circulation Research·Melanie L DartDaniel S Greenspan
Feb 16, 2011·Nature Immunology·Göran K Hansson, Andreas Hermansson
Jun 22, 2011·Circulation·Elena Maganto-GarcíaAndrew H Lichtman
Aug 30, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Faliang ZhuLining Zhang
Sep 29, 2011·Thrombosis and Haemostasis·M Butcher, E Galkina
Nov 9, 2011·Nature Medicine·Christian Weber, Heidi Noels
Jan 28, 2012·Inflammation & Allergy Drug Targets·Eric Toussirot
Sep 11, 2012·Journal of the American College of Cardiology·Kristian ThygesenDaniel R Wagner
Sep 3, 2013·Journal of Clinical & Experimental Cardiology·Jahaira Lopez PastranaXiao-Feng Yang
Feb 24, 2015·F1000prime Reports·John A Ambrose, Manmeet Singh
May 12, 2015·The Journal of Clinical Investigation·Patrick R BurkettVijay K Kuchroo
Dec 18, 2015·Circulation·UNKNOWN Writing Group MembersUNKNOWN Stroke Statistics Subcommittee

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Aug 19, 2020·Medicinal Research Reviews·Indumathi Krishnan-SivadossC Enrique Guerrero-Beltrán

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