Loss of reticulocalbin 2 lowers blood pressure and restrains ANG II-induced hypertension in vivo

American Journal of Physiology. Renal Physiology
Jing LiWeibin Shi


Hypertension affects over 1 billion people worldwide and increases the risk for heart failure, stroke, and chronic kidney disease. Despite high prevalence and devastating impact, its etiology still remains poorly understood for most hypertensive cases. Rcn2, which encodes reticulocalbin 2, is a candidate gene for atherosclerosis that we have previously reported in mice. Here, we identified Rcn2 as a novel regulator of blood pressure in mice. Rcn2 was abundantly expressed in the endothelium and adventitia of normal arteries and was dramatically upregulated in the medial layer of the artery undergoing structural remodeling. Deletion of Rcn2 lowered basal blood pressure and attenuated ANG II-induced hypertension in C57BL/6 mice. siRNA knockdown of Rcn2 dramatically increased production of the nitric oxide (NO) breakdown products nitrite and nitrate by endothelial cells but not by smooth muscle cells. Isolated carotid arteries from Rcn2-/- mice showed an increased sensitivity to the ACh-induced NO-mediated relaxant response compared with arteries of Rcn2+/+ mice. Analysis of a recent meta-data set showed associations of genetic variants near RCN2 with blood pressure in humans. These data suggest that Rcn2 regulates blood pressure a...Continue Reading


Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T N SatoK L Audus
Oct 7, 1997·Circulation Research·A L WongK G Peters
Jan 25, 2000·Circulation·O A Carretero, S Oparil
Feb 19, 2000·Hypertension·H SniederT D Spector
Feb 13, 2001·Journal of Applied Physiology·M H LaughlinE M Price
Mar 10, 2001·The Journal of Clinical Endocrinology and Metabolism·J M Fernandez-RealW Ricart
Dec 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ingrid Fleming, Rudi Busse
Nov 24, 2004·Hypertension·Nina KupperEco J C de Geus
Mar 5, 2005·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Guido BarbagliAndre Cavalcanti
Oct 6, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Susanna S WangAldons J Lusis
Apr 9, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sumathy MohanSherry L Abboud-Werner
Jul 10, 2008·Physiological Genomics·Willem J de LangeCurt D Sigmund
Mar 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Toru KawadaMasaru Sugimachi
May 12, 2009·Nature Genetics·Daniel LevyCornelia M van Duijn
May 12, 2009·Nature Genetics·Christopher Newton-ChehPatricia B Munroe
Aug 28, 2009·The New England Journal of Medicine·Aram V Chobanian
Dec 18, 2010·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Laura L Valdez-VelazquezFernando Rivas
Feb 18, 2011·British Journal of Pharmacology·Michel FélétouPaul M Vanhoutte
Jun 15, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Ani ManichaikulWeibin Shi
Feb 18, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Marie BillaudBrant E Isakson
Oct 16, 2012·The Journal of Clinical Investigation·Colin N YoungRobin L Davisson
Aug 14, 2013·Journal of the American Heart Association·Jessica S RowlanWeibin Shi
Nov 20, 2013·International Journal of Biological Sciences·Peramaiyan RajendranIkuo Nishigaki
Jul 1, 2014·American Journal of Human Genetics·Santhi K GaneshAravinda Chakravarti
Aug 19, 2014·Lancet·UNKNOWN Blood Pressure Lowering Treatment Trialists' Collaboration
Aug 20, 2014·BioMed Research International·Quynh N DinhSophocles Chrissobolis
Dec 23, 2014·Annals of Internal Medicine·Johan SundströmUNKNOWN Blood Pressure Lowering Treatment Trialists' Collaboration
Mar 15, 2015·Circulation Research·Sandosh PadmanabhanAnna F Dominiczak
Apr 29, 2016·BMC Complementary and Alternative Medicine·Putcharawipa ManeesaiPoungrat Pakdeechote

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