Loss of rhythmically bursting neurons in rat medial septum following selective lesion of septohippocampal cholinergic system

Journal of Neurophysiology
E ApartisM H Bassant

Abstract

The medial septum contains cholinergic and GABAergic neurons that project to the hippocampal formation. A significant proportion of the septohippocampal neurons (SHN) exhibit a rhythmically bursting (RB) activity that is involved in the generation of the hippocampal theta rhythm. The neurochemical nature of septal RB neurons is not firmly established. To address this question, the septal unit activity has been recorded in rats after selective destruction of the cholinergic septal neurons by the immunotoxin 192 IgG-saporin. Experiments have been performed in urethan-anesthetized and unanesthetized rats, 14-21 days after lesion. Acetylcholinesterase (AChE) histochemistry revealed a near-complete loss of cholinergic septal neurons and of cholinergic fibers in the hippocampus. The recorded neurons were located in the medial septum-diagonal band of Broca area. A number of these neurons were identified as projecting to the hippocampus (SHN) by their antidromic response to the electrical stimulation of the fimbria-fornix. In urethan-anesthetized lesioned rats, the percentage of RB neurons decreased significantly as compared with controls (17 vs. 41% for SHNs and 5 vs. 19% for unidentified septal neurons). The axonal conduction velocit...Continue Reading

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Citations

Apr 9, 2015·Frontiers in Neuroanatomy·Álvaro García-AvilésFrancisco Olucha-Bordonau
Jan 13, 2006·Journal of Neurochemistry·Luis V Colom
Jun 28, 2005·The European Journal of Neuroscience·Apostolia FragkouliVassilis Pachnis
Mar 31, 2015·The European Journal of Neuroscience·Sergio Martínez-BellverVicent Teruel-Martí
Oct 2, 2014·The Journal of Comparative Neurology·Ana M Sánchez-PérezFrancisco E Olucha-Bordonau
Oct 26, 2018·Developmental Neurobiology·Beryl Y T Chung, Craig D C Bailey
Apr 13, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M H BassantJ M Billard
Jun 28, 2005·The European Journal of Neuroscience·Gábor NyíriTamás F Freund
Apr 20, 2016·Frontiers in Systems Neuroscience·Aleksandr PevznerGene G Gurkoff
Jan 29, 2002·Hippocampus·M H Bassant, F Poindessous-Jazat

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