Loss of Satb2 in the Cortex and Hippocampus Leads to Abnormal Behaviors in Mice

Frontiers in Molecular Neuroscience
Qiong ZhangNing-Ning Song

Abstract

Satb2-associated syndrome (SAS) is a genetic disorder that results from the deletion or mutation of one allele within the Satb2 locus. Patients with SAS show behavioral abnormalities, including developmental delay/intellectual disability, hyperactivity, and symptoms of autism. To address the role of Satb2 in SAS-related behaviors and generate an SAS mouse model, Satb2 was deleted in the cortex and hippocampus of Emx1-Cre; Satb2flox/flox [Satb2 conditional knockout (CKO)] mice. Satb2 CKO mice showed hyperactivity, increased impulsivity, abnormal social novelty, and impaired spatial learning and memory. Furthermore, we also found that the development of neurons in cortical layer IV was defective in Satb2 CKO mice, as shown by the loss of layer-specific gene expression and abnormal thalamocortical projections. In summary, the abnormal behaviors revealed in Satb2 CKO mice may reflect the SAS symptoms associated with Satb2 mutation in human patients, possibly due to defective development of cortical neurons in multiple layers including alterations of their inputs/outputs.

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Citations

Nov 2, 2019·Cell Death and Differentiation·Lei ZhangYu-Qiang Ding
Apr 22, 2020·Proceedings of the National Academy of Sciences of the United States of America·Annalisa PaolinoRodrigo Suárez
Nov 5, 2019·Frontiers in Molecular Neuroscience·Matías Alvarez-SaavedraDavid J Picketts
Sep 30, 2020·Development·Noelia S De León ReyesMarta Nieto
Jan 8, 2021·Journal of Translational Medicine·Jinting GuanGuoli Ji
Mar 28, 2021·Translational Psychiatry·Xiao-Qing WangYu-Qiang Ding
Apr 23, 2021·ELife·Carly V WeissDavid Gokhman
May 26, 2021·Seminars in Cell & Developmental Biology·L Bragg-GonzaloM Nieto
Jun 30, 2021·Annals of Neurology·Emer O'ConnorAndrea Carmine Belin

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Software Mentioned

Activity Monitor
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EthoVision XT
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