Loss of T Follicular Helper Cells in the Peripheral Blood of Patients with Chronic Graft-versus-Host Disease

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
David A KnorrMichael R Verneris

Abstract

B cell antihost antibody production plays a central role in chronic graft-versus-host disease (cGVHD). T follicular helper (TFH) cells drive B cell responses and are implicated in this process. Given differences in cGVHD incidence between umbilical cord blood (UCB) and adult donor transplant recipients, we evaluated TFH cell reconstitution kinetics to define graft source differences and their potential pathogenic role in cGVHD. Although we observed significantly fewer TFH cells in the blood of UCB recipients (versus matched related donors [MRD]) early after transplantation, by 1 year the numbers of TFH cells were similar. Additionally, at both early (day 60) and late (1 year) time points, TFH cell phenotype was predominantly central memory cells in both cohorts. TFH cells were functional and able to produce multiple cytokines (INF-γ, TNF-α, IL-2, IL-17, and IL-21) after stimulation. In contrast to mouse models, where an enhanced frequency of splenic TFH cells contributes to cGVHD, patients with cGVHD showed significantly depleted circulating TFH cells after both UCB and MRD transplantation. Low numbers of TFH cells early after UCB transplantation could directly contribute to less cGVHD in this cohort. Additionally, systemic the...Continue Reading

References

Dec 6, 2000·The Journal of Experimental Medicine·P SchaerliB Moser
Oct 20, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Gerard SociePaul J Martin
Jan 30, 2010·Seminars in Hematology·Paul Szabolcs, Mitchell S Cairo
Feb 15, 2011·Annual Review of Immunology·Shane Crotty
Aug 31, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Caron A JacobsonJerome Ritz
May 12, 2012·Biochemical and Biophysical Research Communications·Xue-yi LiPing Zhu
May 12, 2012·Nature Reviews. Immunology·Bruce R BlazarMehrdad Abedi
Mar 15, 2013·Science Translational Medicine·Salah-Eddine BentebibelHideki Ueno
Jun 28, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Isabelle DebockVéronique Flamand
Oct 2, 2014·The Journal of Clinical Investigation·Jason A DubovskyBruce R Blazar
Dec 3, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Stefanie SarantopoulosJerome Ritz
Dec 17, 2014·Nature Reviews. Clinical Oncology·Troy C LundJohn E Wagner
Dec 23, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Madan H JagasiaMary E D Flowers
Jan 17, 2015·Nature Immunology·Hideki UenoCarola G Vinuesa
Jan 27, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Stefanie SarantopoulosJerome Ritz
Feb 4, 2015·Blood·Stefanie Sarantopoulos, Jerome Ritz

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Citations

Dec 27, 2018·British Journal of Haematology·Xiaoping LiXi Zhang
Sep 1, 2021·Journal of Translational Medicine·Pauline BeurierArsène Mekinian
Jul 16, 2021·Journal of the American Society of Nephrology : JASN·Chiara GuglielmoPaolo Cravedi

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