Loss of the adhesion molecule CEACAM1 is associated with early biochemical recurrence in TMPRSS2:ERG fusion-positive prostate cancers.

International Journal of Cancer. Journal International Du Cancer
Andreas M LuebkeJan Meiners

Abstract

Altered expression of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) has been linked to adverse tumor features in various cancer types. To better understand the role of CEACAM1 in prostate cancer, we analyzed a tissue microarray containing tumor spots from 17,747 prostate cancer patients by means of immunohistochemistry. Normal prostate glands showed intense membranous CEACAM1 positivity. Immunostaining was interpretable in 13,625 cancers and was considered high in 28%, low in 43% and absent in 29% of tumors. Low and lost CEACAM1 expression was strongly linked to adverse tumor features including high classical and quantitative Gleason grade, lymph node metastasis, advanced tumor stage, positive surgical margin, a high number of genomic deletions and early biochemical recurrence (p < 0.0001 each). Subset analysis of molecularly defined cancer subsets revealed that these associations were strongest in V-ets avian erythroblastosis virus E26 oncogene homolog (ERG) fusion-positive cancers and that CEACAM1 loss was prognostic even in tumors harboring genomic deletions of the phosphatase and tensin homolog tumor suppressor (p < 0.0001). Multivariate analysis suggested that CEACAM1 analysis can provide independ...Continue Reading

References

Jan 1, 1996·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·F PrallC Wagener
Feb 20, 1997·International Journal of Cancer. Journal International Du Cancer·K TanakaK Imai
Jul 14, 1998·Nature Medicine·J KononenO P Kallioniemi
Nov 6, 2001·The Journal of Biological Chemistry·Matthew N PoySonia M Najjar
May 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anka ThiesUdo Schumacher
Oct 12, 2004·The Journal of Pathology·Robert KammererWolfgang Zimmermann
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Noam SternOfer Mandelboim
Apr 21, 2007·Pancreas·Diane M SimeoneCraig D Logsdon
Jun 17, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Thorsten SchlommAndreas Erbersdobler
Dec 11, 2008·Pigment Cell & Melanoma Research·Keith S HoekEirikur Steingrimsson
May 23, 2009·American Journal of Clinical Pathology·Thilo GambichlerAlexander Kreuter
Apr 14, 2010·Prostate Cancer and Prostatic Diseases·H ZhaoI P Gorlov
Aug 7, 2010·Methods in Molecular Biology·Martina Mirlacher, Ronald Simon
Mar 18, 2011·International Journal of Cancer. Journal International Du Cancer·Junji IedaHiroki Yamaue
Apr 15, 2011·Journal of Clinical Pathology·Naoki KanomataTakuya Moriya
Jul 28, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sarah MinnerThorsten Schlomm
Dec 18, 2012·Histopathology·Lars EgevadPhilippe Camparo
Feb 2, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Martina KluthSarah Minner
Mar 16, 2013·Cancer Research·Lia BurkhardtRonald Simon
Feb 14, 2014·International Journal of Cancer. Journal International Du Cancer·Martina KluthThorsten Schlomm
Apr 20, 2014·PloS One·Bernhard B SingerHortense Slevogt
Jul 13, 2014·European Urology·Stefan SteurerThorsten Schlomm
Nov 5, 2014·Nature·Yu-Hwa HuangRichard S Blumberg
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Sep 6, 2015·Acta Biochimica Et Biophysica Sinica·Changcheng YangFeng Gao
Nov 7, 2015·Cell·UNKNOWN Cancer Genome Atlas Research Network

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May 18, 2021·International Journal of Cancer. Journal International Du Cancer·Sohei KitazawaRiko Kitazawa

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