Loss of the desmosomal component perp impairs wound healing in vivo.

Dermatology Research and Practice
Veronica G BeaudryL D Attardi

Abstract

Epithelial wound closure is a complex biological process that relies on the concerted action of activated keratinocytes and dermal fibroblasts to resurface and close the exposed wound. Modulation of cell-cell adhesion junctions is thought to facilitate cellular proliferation and migration of keratinocytes across the wound. In particular, desmosomes, adhesion complexes critical for maintaining epithelial integrity, are downregulated at the wound edge. It is unclear, however, how compromised desmosomal adhesion would affect wound reepithelialization, given the need for a delicate balance between downmodulating adhesive strength to permit changes in cellular morphology and maintaining adhesion to allow coordinated migration of keratinocyte sheets. Here, we explore the contribution of desmosomal adhesion to wound healing using mice deficient for the desmosomal component Perp. We find that Perp conditional knockout mice display delayed wound healing relative to controls. Furthermore, we determine that while loss of Perp compromises cell-cell adhesion, it does not impair keratinocyte proliferation and actually enhances keratinocyte migration in in vitro assays. Thus, Perp's role in promoting cell adhesion is essential for wound closu...Continue Reading

References

Oct 21, 1966·Science·R F RushmerG F Odland
Jan 24, 1998·The Journal of Biological Chemistry·M WawersikP A Coulombe
Sep 2, 1999·The New England Journal of Medicine·A J Singer, R A Clark
Jun 24, 2000·Molecular and Cellular Biology·S M WojcikD R Roop
Feb 21, 2002·Trends in Cell Biology·Conrad L LeungRonald K H Liem
May 2, 2002·The Journal of Investigative Dermatology·Stacy MazzalupoPierre A Coulombe
Jan 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Stacy MazzalupoPierre A Coulombe
Jul 4, 2003·Journal of Cell Science·Andrew P SouthJohn A McGrath
Jul 26, 2003·The Journal of Investigative Dermatology·Pierre A Coulombe
Aug 12, 2004·The Journal of Investigative Dermatology·Shannon V SetzerAndrew P Kowalczyk
Sep 25, 2004·Journal of Cellular Physiology·Pierre SavagnerLaurie G Hudson
Nov 25, 2004·Seminars in Cell & Developmental Biology·Taofei Yin, Kathleen J Green
Mar 31, 2005·Cell·Rebecca A IhrieLaura D Attardi
Apr 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Taofei YinKathleen J Green
Feb 24, 2006·Journal of Cell Science·Margaret D KottkeAndrew P Kowalczyk
Jun 13, 2006·Biochimica Et Biophysica Acta·Mechthild Hatzfeld
Oct 16, 2007·The Journal of Investigative Dermatology·Kathleen J Green, Cory L Simpson
Dec 15, 2007·The Journal of Investigative Dermatology·Tatyana SklyarovaJolanda van Hengel
Aug 22, 2008·Molecular Biology of the Cell·Valerie ArnouxPierre Savagner
Aug 30, 2008·International Journal of Cancer. Journal International Du Cancer·Samrat T KunduSorab N Dalal
Jun 3, 2009·The Journal of Clinical Investigation·Raghu Kalluri, Robert A Weinberg
Oct 21, 2009·The Journal of Cell Biology·Preethi VijayarajThomas M Magin
May 1, 1971·The Journal of Cell Biology·W S Krawczyk

❮ Previous
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Citations

Jun 8, 2013·Journal of Pediatric Urology·Istiak MahfuzWei Cheng
May 28, 2013·Journal of Skin Cancer·Kathryn E KingWendy C Weinberg
Apr 16, 2013·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·M C RusuA C Didilescu
May 29, 2014·Cell and Tissue Research·Sanjiv NeupaneJae-Young Kim
Dec 13, 2017·Oral Diseases·P TorresV A Torres
Jan 21, 2018·Cell Death and Differentiation·Zinaida DedeićXin Lu
Sep 26, 2012·Radiation Oncology·Frank HaubnerHolger G Gassner
Jun 3, 2014·BMC Cancer·Björn Ldm Brücher, Ijaz S Jamall
Jul 3, 2015·Cell Communication & Adhesion·Otmar Huber, Iver Petersen
Aug 11, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Daniel Haensel, Xing Dai
Dec 20, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Susan J RehorekJ G M Thewissen

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Methods Mentioned

BETA
biopsies
Biopsy
mechanical dissociation
amputation

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Image Pro

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