PMID: 9188731Jun 1, 1997Paper

Loss of translational entropy in binding, folding, and catalysis

Proteins
L M Amzel

Abstract

There is a loss of translational entropy associated with the formation of a complex between two molecules in solution. Estimation of this contribution is essential for understanding binding, protein-protein association, and catalysis. Based on the cell model of liquids, it is possible to estimate the loss of translational entropy in all these cases. The resulting formulas are straightforward, and the calculations are easy to perform. Comparison of the results with experimental data suggests that the proposed method provides estimates that are much more accurate than those obtained with existing methods.

Citations

May 25, 1999·Protein Science : a Publication of the Protein Society·E García-Hernández, A Hernández-Arana
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hengbin Luo, Kim Sharp
Dec 21, 2002·Protein Science : a Publication of the Protein Society·Enrique García-HernándezMiguel Costas
Oct 25, 2001·Proceedings of the National Academy of Sciences of the United States of America·V K Misra, D E Draper
Feb 19, 2004·RNA·David E Draper
Feb 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sun HurThomas C Bruice
Jul 11, 2009·Chemical Reviews·Huan-Xiang Zhou, Michael K Gilson
Jun 8, 2011·The Journal of Physical Chemistry. B·Narayanan VeeraraghavanSharon Hammes-Schiffer
Dec 4, 2003·Journal of Computational Chemistry·Holger Gohlke, David A Case
Jun 28, 2006·Journal of Computational Chemistry·Lubomír RulísekUlf Ryde
Aug 31, 2000·Annual Review of Biochemistry·J L Popot, D M Engelman
Jun 25, 2008·Annual Review of Biophysics·Jonathan B Chaires
Sep 30, 2008·Chembiochem : a European Journal of Chemical Biology·Sebastian EnckArmin Geyer
Sep 6, 2006·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Jimmy HeimdalUlf Ryde

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.