Loss of Tumor Suppressor ARID1A Protein Expression Correlates with Poor Prognosis in Patients with Primary Breast Cancer

Journal of breast cancer
Hyun Deuk ChoHyun Ju Lee

Abstract

Somatic mutations of the chromatin remodeling AT-rich interactive domain 1A (SWI-like) gene (ARID1A) have been identified in many human cancers, including breast cancer. The purpose of this study was to evaluate the nuclear expression of ARID1A in breast cancers by immunohistochemistry (IHC) and to correlate the findings to clinicopathologic variables including prognostic significance. IHC was performed on tissue microarrays of 476 cases of breast cancer. Associations between ARID1A expression and clinicopathologic characteristics and molecular subtype were retrospectively analyzed. Low expression of ARID1A was found in 339 of 476 (71.2%) cases. Low expression of ARID1A significantly correlated with positive lymph node metastasis (p=0.027), advanced pathologic stage (p=0.001), low Ki-67 labeling index (p=0.003), and negative p53 expression (p=0.017). The ARID1A low expression group had significantly shorter disease-free and overall survival than the ARID1A high expression group (p<0.001 and p<0.001, respectively). Multivariate analysis demonstrated that low expression of ARID1A was a significant independent predictive factor for poor disease-free and overall survival in patients with breast cancer (disease-free survival: hazard...Continue Reading

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Citations

Jan 9, 2020·Acta Biochimica Et Biophysica Sinica·Yiping ZhuLili Sheng
Dec 14, 2018·Molecular Diagnosis & Therapy·Katarzyna KamińskaMarzena Anna Lewandowska
Dec 6, 2020·Journal of Clinical Medicine·Rita Silva-OliveiraCarmen Jerónimo
Mar 15, 2021·Journal of Cancer Research and Clinical Oncology·Corey M GillRaj K Shrivastava
Aug 22, 2020·Pathology, Research and Practice·Si-Hyong JangMee-Hye Oh
Dec 24, 2021·PLoS Genetics·Jake J ReskeRonald L Chandler

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