Loss of Werner syndrome protein function promotes aberrant mitotic recombination

Genes & Development
P R PrinceR J Monnat

Abstract

The chromosome 8p11-12 Werner syndrome (WRN ) locus encodes a RecQ helicase protein of unknown function that possesses both 3' --> 5' helicase and 3' --> 5' exonuclease activities. We show that WRN cell lines display a marked reduction in cell proliferation following mitotic recombination, and generate few viable gene conversion-type recombinants. These findings indicate that WRN plays a role in mitotic recombination, and that a loss of WRN function may promote genetic instability and disease via recombination-initiated mitotic arrest, cell death, or gene rearrangement.

References

Feb 1, 1991·Experimental Cell Research·H Saito, R E Moses
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K FukuchiR J Monnat
Oct 22, 1986·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·L I HuschtschaR Holliday
Jan 1, 1985·Advances in Experimental Medicine and Biology·T MatsumuraM Goto
Jan 1, 1985·Advances in Experimental Medicine and Biology·Y FujiwaraT Matsumura
Oct 1, 1983·Mutation Research·I C LiE H Chu
Sep 1, 1994·Microbiological Reviews·S C KowalczykowskiW M Rehrauer
Dec 31, 1993·Gene·L B Herzing, M S Meyn
Jan 1, 1997·Annual Review of Genetics·S C West
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·R A MarciniakL Guarente
Dec 23, 1998·Trends in Cell Biology·R KanaarD C van Gent
Apr 29, 1999·Human Mutation·M J MoserR J Monnat
Jun 23, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R K Chakraverty, I D Hickson
Dec 22, 1999·Nucleic Acids Research·M J MoserR J Monnat
Apr 8, 2000·Current Opinion in Genetics & Development·P Karran
Apr 8, 2000·Trends in Biochemical Sciences·B Michel
Apr 27, 2000·Trends in Genetics : TIG·J C Shen, L A Loeb
Aug 23, 2000·Nucleic Acids Research·J C Shen, L A Loeb
Nov 10, 2001·Annual Review of Genomics and Human Genetics·A J van BrabantN A Ellis
Nov 1, 1943·Genetics·S E Luria, M Delbrück

❮ Previous
Next ❯

Citations

Jul 31, 2007·Cellular and Molecular Life Sciences : CMLS·L S Cox, R G A Faragher
Dec 17, 2008·Biogerontology·Dharmendra Kumar SinghVilhelm A Bohr
Jan 17, 2004·Biochimie·J A Harrigan, V A Bohr
Apr 16, 2004·DNA Repair·Cristina SwansonRaymond J Monnat
Dec 9, 2003·Mechanisms of Ageing and Development·Vilhelm A Bohr
Jun 11, 2005·Mutation Research·Ali Ozgenc, Lawrence A Loeb
Oct 16, 2003·Trends in Biochemical Sciences·Wolf Dietrich HeyerJachen A Solinger
Nov 13, 2002·Mutation Research·Larry H Thompson, David Schild
Feb 7, 2002·Experimental Gerontology·Robert M Brosh, Vilhelm A Bohr
Apr 24, 2007·Nature Reviews. Molecular Cell Biology·Brian A KudlowRaymond J Monnat
May 18, 2004·Nature Structural & Molecular Biology·Jane KawaokaAnna Marie Pyle
Jul 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Dominika M Wiktor-BrownBevin P Engelward
Jul 15, 2009·Rejuvenation Research·Benjamin P Best
Nov 26, 2003·Molecular Biology of the Cell·Hui GaoClare H McGowan
Nov 18, 2003·Molecular Biology of the Cell·Veronique BlaisClare H McGowan
Oct 27, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Adam LabbéMichel Lebel
Feb 1, 2005·Nucleic Acids Research·Jane Kawaoka, Anna Marie Pyle
Feb 2, 2006·Nucleic Acids Research·Jeanine A HarriganVilhelm A Bohr
May 10, 2006·Nucleic Acids Research·Susan M Bailey, John P Murnane
Apr 14, 2010·Nucleic Acids Research·Prasun Chakraborty, Frank Grosse
Sep 20, 2012·Nucleic Acids Research·Aaron Mendez-BermudezNicola J Royle
Dec 10, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xuefeng RenLuoping Zhang
Jul 5, 2003·Genes & Development·Carla GrandoriRaymond J Monnat
Sep 21, 2002·Molecular and Cellular Biology·Yannick SaintignyRaymond J Monnat
Aug 29, 2003·Molecular and Cellular Biology·Wen-Hsing ChengVilhelm A Bohr
Jul 22, 2006·Annual Review of Genetics·Leonard Wu, Ian D Hickson
Jun 23, 2006·PLoS Genetics·Peter L Houston, James R Broach
Oct 7, 2011·Journal of Nucleic Acids·Sudha Sharma
Aug 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Dominika M Wiktor-BrownBevin P Engelward
Mar 13, 2014·Annual Review of Biochemistry·Deborah L CroteauVilhelm A Bohr
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ashwini S Kamath-LoebLawrence A Loeb
Sep 14, 2014·Cellular and Molecular Life Sciences : CMLS·Annapaola Franchitto, Pietro Pichierri
Oct 26, 2005·The Journal of Cell Biology·Hong YanChinyi Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.