PMID: 16501820Feb 28, 2006Paper

Losses of immunoreactive parvalbumin amacrine and immunoreactive alphaprotein kinase C bipolar cells caused by methylmercury chloride intoxication in the retina of the tropical fish Hoplias malabaricus

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
D M O BonciDora F Ventura

Abstract

To quantify the effects of methylmercury (MeHg) on amacrine and on ON-bipolar cells in the retina, experiments were performed in MeHg-exposed groups of adult trahiras (Hoplias malabaricus) at two dose levels (2 and 6 microg/g, ip). The retinas of test and control groups were processed by mouse anti-parvalbumin and rabbit anti-alphaprotein kinase C (alphaPKC) immunocytochemistry. Morphology and soma location in the inner nuclear layer were used to identify immunoreactive parvalbumin (PV-IR) and alphaPKC (alphaPKC-IR) in wholemount preparations. Cell density, topography and isodensity maps were estimated using confocal images. PV-IR was detected in amacrine cells in the inner nuclear layer and in displaced amacrine cells from the ganglion cell layer, and alphaPKC-IR was detected in ON-bipolar cells. The MeHg-treated group (6 microg/g) showed significant reduction of the ON-bipolar alphaPKC-IR cell density (mean density = 1306 +/- 393 cells/mm2) compared to control (1886 +/- 892 cells/mm2; P < 0.001). The mean densities found for amacrine PV-IR cells in MeHg-treated retinas were 1040 +/- 56 cells/mm2 (2 microg/g) and 845 +/- 82 cells/mm2 (6 microg/g), also lower than control (1312 +/- 31 cells/mm2; P < 0.05), differently from the ...Continue Reading

References

Oct 5, 1979·Science·D A Fox, A J Sillman
Sep 1, 1979·Bulletin of Environmental Contamination and Toxicology·C W Hawryshyn, W C Mackay
Aug 1, 1977·Bulletin of Environmental Contamination and Toxicology·M W Kendall
Jan 1, 1991·Biological Trace Element Research·J SundbergK Bergman
May 1, 1974·Environmental Health Perspectives·C R Angle, M S McIntire
Jan 1, 1969·International Review of Cytology·E R Weibel
Sep 24, 1981·Nature·M R Celio, C W Heizmann
Oct 14, 1994·Biochemical and Biophysical Research Communications·M Kunimoto
Jun 22, 1993·The Journal of Comparative Neurology·H WässleJ Röhrenbeck
Jan 8, 1993·Brain Research·P P SannaF E Bloom
Mar 8, 1993·The Journal of Comparative Neurology·D M Sherry, S Yazulla
Dec 11, 1995·The Science of the Total Environment·O MalmH Kato
Feb 28, 1998·Archives of Environmental Contamination and Toxicology·A C BarbosaJ G Dórea
Jun 13, 1998·Environmental Research·H A KehrigJ P Torres
Apr 29, 2000·International Archives of Occupational and Environmental Health·J DolbecJ Lebel
Jun 17, 2000·Environmental Research·A P de Souza LimaE de Oliveira Santos
Dec 1, 2000·Environmental Research·E da Silva BraboK de Freitas Faial
Jul 24, 2003·Reviews on Environmental Health·Anna F CastoldiLuigi Manzo
Aug 6, 2003·Neurotoxicology·Pavel UrbanMiroslav Cikrt
Sep 29, 2004·Investigative Ophthalmology & Visual Science·Andreas F MackHans-Joachim Wagner
Dec 14, 2004·Ecotoxicology and Environmental Safety·Gilles DurrieuAlain Boudou
May 1, 2005·Environmental Toxicology and Pharmacology·Luiz H M Canto-PereiraDora F Ventura
May 1, 2005·Environmental Toxicology and Pharmacology·D F VenturaL C L Silveira

❮ Previous
Next ❯

Citations

Apr 22, 2009·Experimental Eye Research·Ruth Bejarano-EscobarJavier Francisco-Morcillo
Jun 16, 2010·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Ruth Bejarano-EscobarJavier Francisco-Morcillo
Nov 30, 2007·Environmental Research·Marcelo Fernandes CostaDora Fix Ventura
Oct 2, 2007·Physiology & Behavior·Daniel N WeberMichael J Carvan
Jul 25, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C L TananC A Oliveira-Ribeiro
Oct 16, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·I P LimaC Y I Yan
Dec 3, 2009·Journal of Occupational and Environmental Medicine·Mirella Telles Salgueiro BarboniDora Fix Ventura
Apr 13, 2019·Human & Experimental Toxicology·Ş BilakA Şimşek
Jun 26, 2020·Aquatic Toxicology·Lianguo Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.